The proteins extracellular signal-regulated kinase 1 (ERK1) and ERK2 are the downstream
components of a phosphorelay pathway that conveys growth and mitogenic signals largely …

Cell fate determination requires faithful execution of gene expression programs, which are
increasingly recognized to respond to metabolic inputs. In particular, the family of α …

Fate-determining transcription factors (TFs) can promote lineage-restricted transcriptional
programs from common progenitor states. The inner cell mass (ICM) of mouse blastocysts co …

Fibroblast Growth Factor Receptor (FGFR) signalling plays a critical role in breast embryonal
development, tissue homeostasis, tumorigenesis and metastasis. FGFR, its numerous FGF …

Signaling pathways drive cell fate transitions largely by changing gene expression.
However, the mechanisms for rapid and selective transcriptome rewiring in response to …

Mammalian blastocyst formation involves the specification of the trophectoderm followed by
the differentiation of the inner cell mass into embryonic epiblast and extra-embryonic …

Nucleotide changes in gene regulatory elements are important determinants of neuronal
development and diseases. Using massively parallel reporter assays in primary human cells …

The coordinated regulation of transcriptional networks underpins cellular identity and
developmental progression. RNA polymerase II promoter-proximal pausing (Pol II pausing) …

Signaling by the extracellular signal-regulated kinase (ERK) pathway controls many cellular
processes, including cell division, death, and differentiation. In this second installment of a …

The transcription factor MYC regulates cell proliferation, transformation, and survival in
response to growth factor signaling that is mediated in part by the kinase activity of ERK2 …