Crosslink between calcium and sodium signalling
New Findings What is the topic of this review? This paper overviews the links between Ca2+
and Na+ signalling in various types of cells. What advances does it highlight? This paper …
and Na+ signalling in various types of cells. What advances does it highlight? This paper …
An overview of potential novel mechanisms of action underlying Tumor Treating Fields-induced cancer cell death and their clinical implications
NK Karanam, MD Story - International journal of radiation biology, 2021 - Taylor & Francis
Traditional cancer therapy choices for clinicians are surgery, chemotherapy, radiation and
immune therapy which are used either standalone therapies or in various combinations …
immune therapy which are used either standalone therapies or in various combinations …
[HTML][HTML] Tumor treating fields cause replication stress and interfere with DNA replication fork maintenance: Implications for cancer therapy
NK Karanam, L Ding, A Aroumougame, MD Story - Translational Research, 2020 - Elsevier
Tumor treating fields (TTFields) is a noninvasive physical modality of cancer therapy that
applies low-intensity, intermediate frequency, and alternating electric fields to a tumor …
applies low-intensity, intermediate frequency, and alternating electric fields to a tumor …
Basic and editing mechanisms underlying ion transport and regulation in NCX variants
D Khananshvili - Cell Calcium, 2020 - Elsevier
Abstract Structure-dynamic analysis of archaeal NCX (NCX_Mj) provided new insights into
the underlying mechanisms of ion selectivity, ion-coupled alternating access, ion occlusion …
the underlying mechanisms of ion selectivity, ion-coupled alternating access, ion occlusion …
Structure-based function and regulation of NCX variants: updates and challenges
D Khananshvili - International Journal of Molecular Sciences, 2022 - mdpi.com
The plasma-membrane homeostasis Na+/Ca2+ exchangers (NCXs) mediate Ca2+
extrusion/entry to dynamically shape Ca2+ signaling/in biological systems ranging from …
extrusion/entry to dynamically shape Ca2+ signaling/in biological systems ranging from …
Structural features of ion transport and allosteric regulation in sodium-calcium exchanger (NCX) proteins
M Giladi, I Tal, D Khananshvili - Frontiers in physiology, 2016 - frontiersin.org
Na+/Ca2+ exchanger (NCX) proteins extrude Ca2+ from the cell to maintain cellular
homeostasis. Since NCX proteins contribute to numerous physiological and …
homeostasis. Since NCX proteins contribute to numerous physiological and …
Transcriptional and epigenetic regulation of ncx1 and ncx3 in the brain
L Formisano, N Guida, L Mascolo, A Serani, G Laudati… - Cell calcium, 2020 - Elsevier
Abstract Sodium-calcium exchanger (NCX) 1 and 3, have been demonstrated to play a
relevant role in controlling the intracellular homeostasis of sodium and calcium ions in …
relevant role in controlling the intracellular homeostasis of sodium and calcium ions in …
Asymmetric preorganization of inverted pair residues in the sodium-calcium exchanger
In analogy with many other proteins, Na+/Ca2+ exchangers (NCX) adapt an inverted twofold
symmetry of repeated structural elements, while exhibiting a functional asymmetry by …
symmetry of repeated structural elements, while exhibiting a functional asymmetry by …
Dynamic distinctions in the Na+/Ca2+ exchanger adopting the inward-and outward-facing conformational states
Na+/Ca 2+ exchanger (NCX) proteins operate through the alternating access mechanism,
where the ion-binding pocket is exposed in succession either to the extracellular or the …
where the ion-binding pocket is exposed in succession either to the extracellular or the …
Structural dynamics of Na+ and Ca2+ interactions with full-size mammalian NCX
M Giladi, L Fojtík, T Strauss, B Da'adoosh… - Communications …, 2024 - nature.com
Abstract Cytosolic Ca2+ and Na+ allosterically regulate Na+/Ca2+ exchanger (NCX)
proteins to vary the NCX-mediated Ca2+ entry/exit rates in diverse cell types. To resolve the …
proteins to vary the NCX-mediated Ca2+ entry/exit rates in diverse cell types. To resolve the …