Corneal neovascularization: an anti-VEGF therapy review

JH Chang, NK Garg, E Lunde, KY Han, S Jain… - Survey of …, 2012 - Elsevier
Corneal neovascularization is a serious condition that can lead to a profound decline in
vision. The abnormal vessels block light, cause corneal scarring, compromise visual acuity …

Current and emerging therapies for corneal neovascularization

D Roshandel, M Eslani, A Baradaran-Rafii… - The ocular …, 2018 - Elsevier
The cornea is unique because of its complete avascularity. Corneal neovascularization
(CNV) can result from a variety of etiologies including contact lens wear; corneal infections; …

Therapeutic approaches for corneal neovascularization

S Feizi, AA Azari, S Safapour - Eye and Vision, 2017 - Springer
Angiogenesis refers to new blood vessels that originate from pre-existing vascular
structures. Corneal neovascularization which can lead to compromised visual acuity occurs …

Novel anti (lymph) angiogenic treatment strategies for corneal and ocular surface diseases

F Bock, K Maruyama, B Regenfuss, D Hos… - Progress in retinal and …, 2013 - Elsevier
The cornea is one of the few tissues which actively maintain an avascular state, ie the
absence of blood and lymphatic vessels (corneal [lymph] angiogenic privilege). Nonetheless …

[HTML][HTML] IL-17 and VEGF are necessary for efficient corneal nerve regeneration

Z Li, AR Burns, L Han, RE Rumbaut… - The American journal of …, 2011 - Elsevier
The contribution of acute inflammation to sensory nerve regeneration was investigated in the
murine cornea using a model of corneal abrasion that removes the stratified epithelium and …

Upadacitinib inhibits corneal inflammation and neovascularization by suppressing M1 macrophage infiltration in the corneal alkali burn model

J Yu, Y Shen, J Luo, J Jin, P Li, P Feng… - International …, 2023 - Elsevier
Alkali burn-induced corneal inflammation and subsequent corneal neovascularization
(CNV) are major causes of corneal opacity and vision loss. M1 macrophages play a central …

Pharmacokinetics, pharmacodynamics and pre-clinical characteristics of ophthalmic drugs that bind VEGF

MW Stewart - Expert review of clinical pharmacology, 2014 - Taylor & Francis
Drugs that prevent the binding of VEGF to its trans-membrane cognate receptors have
revolutionized the treatment of the most important chorioretinal vascular disorders: exudative …

Topical ranibizumab as a treatment of corneal neovascularization

G Ferrari, MH Dastjerdi, A Okanobo, SF Cheng… - Cornea, 2013 - journals.lww.com
Purpose: To examine the effect of topical ranibizumab on clinically stable corneal
neovascularization (NV). Methods: This was a prospective, open-label, monocentric …

Pharmacokinetics of bevacizumab after topical and intravitreal administration in human eyes

E Moisseiev, M Waisbourd, E Ben-Artsi… - Graefe's Archive for …, 2014 - Springer
Background Topical bevacizumab is a potential treatment modality for corneal
neovascularization, and several recent studies have demonstrated its efficacy. No previous …

Angiogenesis and lymphangiogenesis in corneal transplantation–A review

W Zhong, M Montana, SM Santosa, ID Isjwara… - Survey of …, 2018 - Elsevier
Corneal transplantation has been proven effective for returning the gift of sight to those
affected by corneal disorders such as opacity, injury, and infections that are a leading cause …