The coordinated development of the nervous system requires fidelity in the expression of
specific genes determining the different neural cell phenotypes. Stem cell fate decisions …

Epigenetics refers to stable and long-term alterations of cellular traits that are not caused by
changes in the DNA sequence per se. Rather, covalent modifications of DNA and histones …

Multiple non-animal-based test methods have never been formally validated. In order to use
such new approach methods (NAMs) in a regulatory context, criteria to define their …

Developmental neurotoxicity (DNT) and many forms of reproductive toxicity (RT) often
manifest themselves in functional deficits that are not necessarily based on cell death, but …

Alcohol intoxicated cells broadly alter their metabolites–among them methyl and acetic acid
can alter the DNA and histone epigenetic codes. Together with the promiscuous effect of …

Test systems to identify developmental toxicants are urgently needed. A combination of
human stem cell technology and transcriptome analysis was to provide a proof of concept …

Information on design principles governing transcriptome changes upon transition from safe
to hazardous drug concentrations or from tolerated to cytotoxic drug levels are important for …

Safety sciences and the identification of chemical hazards have been seen as one of the
most immediate practical applications of human pluripotent stem cell technology. Protocols …

The superordinate principles governing the transcriptome response of differentiating cells
exposed to drugs are still unclear. Often, it is assumed that toxicogenomics data reflect the …

Abstract Polycomb Repressive Complex 2 (PRC2) mediates transcriptional silencing by
catalyzing histone H3 lysine 27 trimethylation (H3K27me3), but its role in the maturation of …