Inflammation is currently considered a prime target for the development of new stroke
therapies. In the acute phase of ischemic stroke, microglia are activated and then circulating …

Inflammation is a hallmark of stroke pathology. The cytokines, tumor necrosis factor (TNF),
interleukin (IL)-1, and IL-6, modulate tissue injury in experimental stroke and are therefore …

Rodent stroke models provide the experimental backbone for the in vivo determination of the
mechanisms of cell death and neural repair, and for the initial testing of neuroprotective …

The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin
domain-containing 3 (NLRP3) inflammasome is a member of the NLR family of inherent …

Cerebral ischemia (stroke) triggers a complex series of biochemical and molecular
mechanisms that impairs the neurologic functions through breakdown of cellular integrity …

Background: The existence of cerebral reperfusion injury in human beings remains
controversial. Thus, we aimed to explore the presence of reperfusion injury in acute …

Inflammation is an innate immune response to infection or tissue damage that is designed to
limit harm to the host, but contributes significantly to ischemic brain injury following stroke …

The blood-brain barrier (BBB) is a dynamic but solid shield in the cerebral microvascular
system. It plays a pivotal role in maintaining central nervous system (CNS) homeostasis by …

For the last two decades, researchers have placed hopes in a new era in which a
combination of reperfusion and neuroprotection would revolutionize the treatment of stroke …

1. Stroke is the neurological evidence of a critical reduction of cerebral blood flow in a
circumscribed part of the brain, resulting from the sudden or gradually progressing …