In eukaryotes, the spindle-assembly checkpoint (SAC) is a ubiquitous safety device that
ensures the fidelity of chromosome segregation in mitosis. The SAC prevents chromosome …

The formation of heterochromatin, which requires methylation of histone H3 at lysine 9 and
the subsequent recruitment of chromodomain proteins such as heterochromatin protein …

The catalytic activity of the MPS1 kinase is crucial for the spindle assembly checkpoint and
for chromosome biorientation on the mitotic spindle. We report that the small molecule …

The microtubule-binding interface of the kinetochore is of central importance in chromosome
segregation. Although kinetochore components that stabilize, translocate on, and affect the …

For proper partitioning of chromosomes in mitosis, the chromosomal passenger complex
(CPC) including Aurora B and survivin must be localized at the center of paired …

Conditional temperature-sensitive (ts) mutations are valuable reagents for studying essential
genes in the yeast Saccharomyces cerevisiae. We constructed 787 ts strains, covering 497 …

Mitosis and meiosis are remarkable processes during which cells undergo profound
changes in their structure and physiology. These events are orchestrated with a precision …

The strategy of clinically targeting cancerous cells at their most vulnerable state during
mitosis has instigated numerous studies into the mitotic cell death (MCD) pathway. As the …

Kinetochores are large protein assemblies built on chromosomal loci named centromeres.
The main functions of kinetochores can be grouped under four modules. The first module, in …

The Aurora protein kinase family (consisting of Aurora-A,-B and-C) is an important group of
enzymes that controls several aspects of cell division in mammalian cells. Dysfunction of …