Messenger RNA (mRNA) has emerged as a new category of therapeutic agent to prevent
and treat various diseases. To function in vivo, mRNA requires safe, effective and stable …

Conspectus Since the US Food and Drug Administration (FDA) granted emergency use
authorization for two mRNA vaccines against SARS-CoV-2, mRNA-based technology has …

Cell therapy has revolutionized the treatment of various diseases, such as cancers, genetic
disorders, and autoimmune diseases. Currently, most cell therapy products rely on ex vivo …

Since its discovery, the CRISPR/Cas technology has rapidly become an essential tool in
modern biomedical research. The opportunities to specifically modify and correct genomic …

Lipid nanoparticle (LNP)-based drug delivery systems have become the most clinically
advanced non-viral delivery technology. LNPs can encapsulate and deliver a wide variety of …

Neurodegeneration is characterized by progressive, disabling, and incurable neurological
disorders with the massive loss of specific neurons. As one of the most promising potential …

Adipose stem cells (ASCs) have attracted considerable attention as potential therapeutic
agents due to their ability to promote tissue regeneration. However, their limited tissue repair …

The recent development of RNA‐based therapeutics in delivering nucleic acids for gene
editing and regulating protein translation has led to the effective treatment of various …

The coronavirus (COVID-19) pandemic has underscored the critical role of mRNA-based
vaccines as powerful, adaptable, readily manufacturable, and safe methodologies for …

The use of siRNA therapeutics to treat cancer is a very promising approach. However,
specific delivery of siRNAs to tumors remains a major challenge. The recent success of …