Abstract Prominin-1 (CD133) is a cholesterol-binding membrane glycoprotein selectively
associated with highly curved and prominent membrane structures. It is widely recognized …

In vertebrate vision, photons are detected by highly specialized sensory cilia called outer
segments. Photoreceptor outer segments form by remodeling the membrane of a primary …

As signalling organelles, cilia regulate their G protein-coupled receptor content by
ectocytosis, a process requiring localised actin dynamics to alter membrane shape …

Abstract Background Inherited retinal dystrophies (IRDs) are a group of debilitating visual
disorders characterized by the progressive degeneration of photoreceptors, which ultimately …

Extracellular membrane vesicles (EVs) offer promising values in various medical fields, eg,
as biomarkers in liquid biopsies or as native (or bioengineered) biological nanocarriers in …

In humans, inositol polyphosphate-5-phosphatase e (INPP5E) mutations cause retinal
degeneration as part of Joubert and MORM syndromes and can also cause non-syndromic …

Vision is arguably our most important sense, and its loss brings substantial limitations to
daily life for affected individuals. Light is perceived in retinal photoreceptors (PRs), which are …

Abstract In humans, inositol polyphosphate-5-phosphatase e (INPP5E) mutations cause
retinal degeneration as part of Joubert and MORM syndromes and can also cause non …

Cilia Signaling in Development and Disease, Volume 155 in the Current Topics in
Developmental Biology series, highlights new advances in the field, with this new volume …

Visual signal transduction takes place within a stack of flattened membranous 'discs'
enclosed within the light-sensitive photoreceptor outer segment. The highly curved rims of …