The nucleolus is the most prominent nuclear body and serves a fundamentally important biological role as a site of ribonucleoprotein particle assembly, primarily dedicated to …
All living things experience an increase in entropy, manifested as a loss of genetic and epigenetic information. In yeast, epigenetic information is lost over time due to the …
Extrachromosomal circular DNA elements (eccDNAs) have been described in the literature for several decades, and are known for their broad existence across different species …
Y Hori, C Engel, T Kobayashi - Nature reviews Molecular cell biology, 2023 - nature.com
One of the first biological machineries to be created seems to have been the ribosome. Since then, organisms have dedicated great efforts to optimize this apparatus. The …
The sirtuin family of nicotinamide adenine dinucleotide–dependent deacylases (SIRT1–7) are thought to be responsible, in large part, for the cardiometabolic benefits of lean diets and …
S Kasai, S Shimizu, Y Tatara, J Mimura, K Itoh - Biomolecules, 2020 - mdpi.com
Reactive oxygen species (ROS) are byproducts of aerobic respiration and signaling molecules that control various cellular functions. Nrf2 governs the gene expression of …
Aging is an inevitable outcome of life, characterized by progressive decline in tissue and organ function and increased risk of mortality. Accumulating evidence links aging to genetic …
S Pal, JK Tyler - Science advances, 2016 - science.org
Over the past decade, a growing number of studies have revealed that progressive changes to epigenetic information accompany aging in both dividing and nondividing cells …
Abstract The sirtuins (SIRT1–7) are a family of nicotinamide adenine dinucleotide (NAD+)- dependent deacylases with remarkable abilities to prevent diseases and even reverse …