In vivo two-photon calcium imaging (2PCI) is a technique used for recording neuronal
activity in the intact brain. It is based on the principle that, when neurons fire action …

Recent progress in fluorescence imaging allows neuroscientists to observe the dynamics of
thousands of individual neurons, identified genetically or by their connectivity, across …

Microglia are the CNS resident immune cells that react to misfolded proteins through pattern
recognition receptor ligation and activation of inflammatory pathways. Here, we studied how …

Psilocybin is a serotonergic psychedelic with untapped therapeutic potential. There are hints
that the use of psychedelics can produce neural adaptations, although the extent and …

Neurons in the developing brain undergo extensive structural refinement as nascent circuits
adopt their mature form. This physical transformation of neurons is facilitated by the …

We developed a miniaturized two-photon microscope (MINI2P) for fast, high-resolution,
multiplane calcium imaging of over 1,000 neurons at a time in freely moving mice. With a …

Microglia are crucial for maintaining brain health and neuron function. Here, we report that
microglia establish connections with neurons using tunneling nanotubes (TNTs) in both …

Despite successful clot retrieval in large vessel occlusion stroke,∼ 50% of patients have an
unfavorable clinical outcome. The mechanisms underlying this functional reperfusion failure …

Alzheimer's disease is the most prevalent type of dementia and is caused by the deposition
of extracellular amyloid‐beta and abnormal tau phosphorylation. Neuroinflammation has …

Chronic, pathological pain remains a global health problem and a challenge to basic and
clinical sciences. A major obstacle to preventing, treating, or reverting chronic pain has been …