Context-specific regulation and function of mRNA alternative polyadenylation
S Mitschka, C Mayr - Nature Reviews Molecular Cell Biology, 2022 - nature.com
Alternative cleavage and polyadenylation (APA) is a widespread mechanism to generate
mRNA isoforms with alternative 3′ untranslated regions (UTRs). The expression of …
mRNA isoforms with alternative 3′ untranslated regions (UTRs). The expression of …
Insights gained from RNA editing targeted by the CRISPR-Cas13 family
L Liu, DS Pei - International Journal of Molecular Sciences, 2022 - mdpi.com
Clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated
protein (Cas) systems, especially type II (Cas9) systems, have been widely developed for …
protein (Cas) systems, especially type II (Cas9) systems, have been widely developed for …
Alternative polyadenylation transcriptome-wide association study identifies APA-linked susceptibility genes in brain disorders
Alternative polyadenylation (APA) plays an essential role in brain development; however,
current transcriptome-wide association studies (TWAS) largely overlook APA in nominating …
current transcriptome-wide association studies (TWAS) largely overlook APA in nominating …
Accurate transcriptome-wide identification and quantification of alternative polyadenylation from RNA-seq data with APAIQ
Alternative polyadenylation (APA) enables a gene to generate multiple transcripts with
different 3′ ends, which is dynamic across different cell types or conditions. Many …
different 3′ ends, which is dynamic across different cell types or conditions. Many …
[HTML][HTML] Multi-color RNA imaging with CRISPR-Cas13b systems in living cells
Visualizing RNA dynamics is important for understanding RNA function. Catalytically dead
(d) CRISPR-Cas13 systems have been established to image and track RNAs in living cells …
(d) CRISPR-Cas13 systems have been established to image and track RNAs in living cells …
[HTML][HTML] Advances of CRISPR-Cas13 system in COVID-19 diagnosis and treatment
The ongoing global pandemic of coronavirus disease 2019 (COVID-19), caused by the
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in over 570 …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in over 570 …
CRISPR-Cas13 in malaria parasite: Diagnosis and prospective gene function identification
E Quansah, Y Chen, S Yang, J Wang, D Sun… - Frontiers in …, 2023 - frontiersin.org
Malaria caused by Plasmodium is still a serious public health problem. Genomic editing is
essential to understand parasite biology, elucidate mechanical pathways, uncover gene …
essential to understand parasite biology, elucidate mechanical pathways, uncover gene …
Downregulation of apoptotic repressor AVEN exacerbates cardiac injury after myocardial infarction
P Yu, S Song, X Zhang, S Cui, G Wei… - Proceedings of the …, 2023 - National Acad Sciences
Myocardial infarction (MI) is a leading cause of heart failure (HF), associated with morbidity
and mortality worldwide. As an essential part of gene expression regulation, the role of …
and mortality worldwide. As an essential part of gene expression regulation, the role of …
Precision Transcriptome Editing
C Chen, LS Qi - ACS Synthetic Biology, 2024 - ACS Publications
Manipulating RNA species in mammalian cells has emerged as an important strategy for
precise gene expression control. Here we review recent advances in precision …
precise gene expression control. Here we review recent advances in precision …
Alternative polyadenylation regulation: insights from sequential polyadenylation
P Tang, Y Zhou - Transcription, 2022 - Taylor & Francis
The processing of the proximal and distal poly (A) sites in alternative polyadenylation (APA)
has long been thought to independently occur on pre-mRNAs during transcription. However …
has long been thought to independently occur on pre-mRNAs during transcription. However …