Roles of mitochondria in neutrophils

Z Cao, M Zhao, H Sun, L Hu, Y Chen, Z Fan - Frontiers in immunology, 2022 - frontiersin.org
Neutrophils are the most abundant leukocyte in human blood. They are critical for fighting
infections and are involved in inflammatory diseases. Mitochondria are indispensable for …

Application of modified mRNA in somatic reprogramming to pluripotency and directed conversion of cell fate

AYL Wang - International journal of molecular sciences, 2021 - mdpi.com
Modified mRNA (modRNA)-based somatic reprogramming is an effective and safe approach
that overcomes the genomic mutation risk caused by viral integrative methods. It has …

Unravelling molecular mechanisms in atherosclerosis using cellular models and omics technologies

D Kardassis, C Vindis, CS Stancu, L Toma… - Vascular …, 2024 - Elsevier
Despite the discovery and prevalent clinical use of potent lipid-lowering therapies, including
statins and PCSK9 inhibitors, cardiovascular diseases (CVD) caused by atherosclerosis …

PTP1B phosphatase dampens iPSC-derived neutrophil motility and antimicrobial function

MA Giese, DA Bennin, TJ Schoen… - Journal of Leukocyte …, 2024 - academic.oup.com
Neutrophils are rapidly recruited to sites of infection and are critical for pathogen clearance.
Therapeutic use of primary neutrophils has been limited, as they have a short lifespan and …

Sourcing cells for in vitro models of human vascular barriers of inflammation

MC McCloskey, VZ Zhang, SD Ahmad… - Frontiers in Medical …, 2022 - frontiersin.org
The vascular system plays a critical role in the progression and resolution of inflammation.
The contributions of the vascular endothelium to these processes, however, vary with tissue …

PTP1B phosphatase puts a brake on iPSC-derived neutrophil motility and antimicrobial function

MA Giese, DA Bennin, TJ Schoen, AN Peterson… - BioRxiv, 2023 - biorxiv.org
Neutrophils are rapidly recruited to sites of infection and are critical for pathogen clearance.
Neutropenic patients are at high risk for fungal and bacterial infections and can benefit from …

Neutrophil generation from hematopoietic progenitor cells and induced pluripotent stem cells (iPSCs): Potential applications

A Jafarzadeh, M Motaghi, SK Patra, Z Jafarzadeh… - Cytotherapy, 2024 - Elsevier
Neutrophils are the most frequent immune cell type in peripheral blood, performing an
essential role against pathogens. People with neutrophil deficiencies are susceptible to …

[HTML][HTML] GATA1-deficient human pluripotent stem cells generate neutrophils with improved antifungal immunity that is mediated by the integrin CD18

AS Wagner, FM Smith, DA Bennin, JA Votava… - …, 2024 - pmc.ncbi.nlm.nih.gov
Author Summary Neutrophils are important first responders to fungal infections, and
understanding their antifungal functions is essential to better elucidating disease dynamics …