Viral modulation of the DNA damage response and innate immunity: two sides of the same coin

A Lopez, RN Doyle, C Sandoval, K Nisson… - Journal of molecular …, 2022 - Elsevier
The DDR consists of multiple pathways that sense, signal, and respond to anomalous DNA.
To promote efficient replication, viruses have evolved to engage and even modulate the …

Sneaking into the viral safe-houses: Implications of host components in regulating integrity and dynamics of rotaviral replication factories

P Chandra, S Banerjee, P Saha… - Frontiers in Cellular …, 2022 - frontiersin.org
The biology of the viral life cycle essentially includes two structural and functional entities—
the viral genome and protein machinery constituting the viral arsenal and an array of host …

Rotavirus spike protein VP4 mediates viroplasm assembly by association to actin filaments

J Vetter, G Papa, M Seyffert, K Gunasekera… - Journal of …, 2022 - Am Soc Microbiol
Rotavirus (RV) viroplasms are cytosolic inclusions where both virus genome replication and
primary steps of virus progeny assembly take place. A stabilized microtubule cytoskeleton …

Codon usage similarity between viral and some host genes suggests a codon-specific translational regulation

K Jitobaom, S Phakaratsakul, T Sirihongthong… - Heliyon, 2020 - cell.com
The codon usage pattern is a specific characteristic of each species; however, the codon
usage of all of the genes in a genome is not uniform. Intriguingly, most viruses have codon …

Conserved rotavirus NSP5 and VP2 domains interact and affect viroplasm

A Buttafuoco, K Michaelsen, K Tobler… - Journal of …, 2020 - Am Soc Microbiol
One step of the life cycle common to all rotaviruses (RV) studied so far is the formation of
viroplasms, membrane-less cytosolic inclusions providing a microenvironment for early …

Interference of pseudorabies virus infection on functions of porcine granulosa cells via apoptosis modulated by MAPK signaling pathways

L Deng, W Min, S Guo, J Deng, X Wu, D Tong, A Yuan… - Virology Journal, 2024 - Springer
Background Pseudorabies virus (PRV) is one of the major viral pathogens leading to
reproductive disorders in swine. However, little is known about the effects of PRV infection …

Actin-dependent nonlytic rotavirus exit and infectious virus morphogenetic pathway in nonpolarized cells

Ó Trejo-Cerro, C Eichwald, EM Schraner… - Journal of …, 2018 - Am Soc Microbiol
During the late stages of rotavirus morphogenesis, the surface proteins VP4 and VP7 are
assembled onto the previously structured double-layered virus particles to yield a triple …

The capsid protein VP1 of coxsackievirus B induces cell cycle arrest by up-regulating heat shock protein 70

Y Wang, S Zhao, Y Chen, T Wang, C Dong… - Frontiers in …, 2019 - frontiersin.org
Manipulating cell cycle is one of the common strategies used by viruses to generate
favorable cellular environment to facilitate viral replication. Coxsackievirus B (CVB) is one of …

Treading a HOSTile path: mapping the dynamic landscape of host cell–rotavirus interactions to explore novel host-directed curative dimensions

U Patra, U Mukhopadhyay, A Mukherjee, S Dutta… - Virulence, 2021 - Taylor & Francis
Viruses are intracellular pathogens and are dependent on host cellular resources to carry
out their cycles of perpetuation. Obtaining an integrative view of host–virus interaction is of …

Oral application of recombinant Bacillus subtilis spores to dogs results in a humoral response against specific Echinococcus granulosus paramyosin and tropomyosin …

CM Vogt, MT Armúa-Fernández, K Tobler… - Infection and …, 2018 - Am Soc Microbiol
Bacillus subtilis is known as an endospore-and biofilm-forming bacterium with probiotic
properties. We have recently developed a method for displaying heterologous proteins on …