Current status and limitations of myocardial infarction large animal models in cardiovascular translational research

HS Shin, HH Shin, Y Shudo - Frontiers in bioengineering and …, 2021 - frontiersin.org
Establishing an appropriate disease model that mimics the complexities of human
cardiovascular disease is critical for evaluating the clinical efficacy and translation success …

Multi-organ protective effects of curcumin nanoparticles on drug-induced acute myocardial infarction in rats with type 1 diabetes mellitus

PM Boarescu, I Boarescu, AE Bulboacă, IC Bocșan… - Applied Sciences, 2021 - mdpi.com
The objectives of this study were to investigate the cardio-protective, hepatoprotective and
nephroprotective effects of curcumin nanoparticle (NC) pretreatment compared to …

Vitamin D as a modulator of molecular pathways involved in CVDs: evidence from preclinical studies

S Dutta, S Aboo, A Ismail - Life Sciences, 2024 - Elsevier
Vitamin D deficiency (VDD) is a widespread global health issue, affecting nearly a billion
individuals worldwide, and mounting evidence links it to an increased risk of cardiovascular …

[HTML][HTML] Protective effects of 2-methoxyestradiol on acute isoproterenol-induced cardiac injury in rats

RH Hareeri, AM Alam, AM Bagher, AJ Alamoudi… - Saudi Pharmaceutical …, 2023 - Elsevier
Myocardial injury (MI) is an important pathological driver of mortality worldwide., and arises
as a result of imbalances between myocardial oxygen demand and supply. In MI, oxidative …

Protective effects of silver nanoparticles in isoproterenol-induced myocardial infarction in rats

W Arozal, ER Monayo, AJ Barinda, DP Perkasa… - Frontiers in …, 2022 - frontiersin.org
Background Silver nanoparticles (AgNPs) are widely used in the medical field, including
cardiovascular. However, limited research has investigated the effect of AgNPs on the …

Thymoquinone dose-dependently attenuates myocardial injury induced by isoproterenol in rats via integrated modulations of oxidative stress, inflammation, apoptosis …

MM Farag, AA Khalifa, WF Elhadidy… - … Archives of Pharmacology, 2021 - Springer
As rats develop myocardial infarction (MI) like lesions when injected with large doses of
isoproterenol (ISO), this investigation was designed to evaluate the dose-dependent effects …

Enhanced cardioprotective activity of ferulic acid-loaded solid lipid nanoparticle in an animal model of myocardial injury

I Ishtiaq, A Zeb, H Badshah, A Alattar… - Toxicology and Applied …, 2023 - Elsevier
Myocardial infarction results in an increased inflammatory and oxidative stress response in
the heart, and reducing inflammation and oxidative stress after MI may offer protective effects …

Cardioprotective effects of plant-based silver nanoparticles: Describing a modern drug

N Xu, T Zhang, X Wang, L Wang - Inorganic Chemistry Communications, 2023 - Elsevier
Regarding applicative, facile, green chemical research, a bio-inspired approach is being
reported for the synthesis of Ag nanoparticles by Rumex alpinus L as a natural reducing and …

A review on experimental surgical models and anesthetic protocols of heart failure in rats

A Farag, AS Mandour, H Hendawy… - Frontiers in Veterinary …, 2023 - frontiersin.org
Heart failure (HF) is a serious health and economic burden worldwide, and its prevalence is
continuously increasing. Current medications effectively moderate the progression of …

Alpha-terpineol prevents myocardial damage against isoproterenol-MI induced in Wistar-Kyoto rats: new possible to promote cardiovascular integrity

ET Paulino, AKBF Rodrigues, MLDP Machado… - Life Sciences, 2022 - Elsevier
Alpha-terpineol (TPN) is one of the major components of the resin obtained from Protium
heptaphyllum. This plant has been utilized as medicine by Brazilian indigenous tribes to …