Neuroinflammation is a physiological protective response in the context of infection and
injury. However, neuroinflammation, especially if chronic, may also drive …

Highlights•Neurotrophins have been linked to several disorders, including AD and
depression.•Complex biology has led to difficulties in identifying suitable drug …

Increased life expectancy in combination with modern life style and high prevalence of
obesity are important risk factors for development of neurodegenerative diseases …

Microglia, the parenchymal immune cells of the central nervous system, orchestrate
neuroinflammation in response to infection or damage, and promote tissue repair. However …

Recent evidence suggests a possible relationship between the immune system and
schizophrenia spectrum disorders (SSDs), as neuroinflammation appears to play a role in …

Alzheimer's disease (AD) is the most common neurodegenerative disorder and results in
severe neurodegeneration and progressive cognitive decline. Neurotrophins are growth …

Alzheimer's Disease (AD) is an incurable and debilitating progressive, neurodegenerative
disorder which is the leading cause of dementia worldwide. Neuropathologically, AD is …

BNN27, a C17-spiroepoxy derivative of DHEA, was shown to have antiapoptotic properties
via mechanisms involving the nerve growth factor receptors (tropomyosin-related kinase A …

Rationale Several lines of evidence indicate that the neurosteroid dehydroepiandrosterone
(DHEA) is involved in anxiety. BNN27 is a new DHEA derivative lacking steroidogenic …

Since the discovery of the nervous system's ability to produce steroid hormones, numerous
studies have demonstrated their importance in modulating neuronal excitability. These …