[HTML][HTML] Sialic acid and Siglec receptors in tumor immunity and immunotherapy

NR Mantuano, H Läubli - Seminars in Immunology, 2024 - Elsevier
Immunotherapy, including immune checkpoint inhibition, has transformed cancer therapy in
recent years, providing new and potentially curative options for patients with even advanced …

The glycosyltransferase ST3GAL4 drives immune evasion in acute myeloid leukemia by synthesizing ligands for the glyco-immune checkpoint receptor Siglec-9

V Krishnamoorthy, J Daly, J Kim, L Piatnitca, KA Yuen… - Leukemia, 2024 - nature.com
Immunotherapy has demonstrated promise as a treatment for acute myeloid leukemia
(AML). However, there is still an urgent need to identify new molecules that inhibit the …

[HTML][HTML] Roles for Siglec-glycan interactions in regulating immune cells

SY Lin, EN Schmidt, K Takahashi-Yamashiro… - Seminars in …, 2025 - Elsevier
Cell surface complex carbohydrates, known as glycans, are positioned to be the first point of
contact between two cells. Indeed, interactions between glycans with glycan-binding can …

Human-augmented large language model-driven selection of glutathione peroxidase 4 as a candidate blood transcriptional biomarker for circulating erythroid cells

B Subba, M Toufiq, F Omi, M Yurieva, T Khan… - Scientific Reports, 2024 - nature.com
The identification of optimal candidate genes from large-scale blood transcriptomic data is
crucial for developing targeted assays to monitor immune responses. Here, we introduce a …

Sialylation Inhibition Can Partially Revert Acquired Resistance to Enzalutamide in Prostate Cancer Cells

EA Goode, M Orozco-Moreno, K Hodgson… - …, 2024 - pmc.ncbi.nlm.nih.gov
Simple Summary Prostate cancer is the most common cancer in men and a major cause of
cancer-related deaths around the world. Prostate cancer that has spread to other parts of the …

Sialic acid blockade inhibits the metastatic spread of prostate cancer to bone

K Hodgson, M Orozco-Moreno, EA Goode, M Fisher… - …, 2024 - thelancet.com
Background Bone metastasis is a common consequence of advanced prostate cancer.
Bisphosphonates can be used to manage symptoms, but there are currently no curative …

Androgens suppress the sialyltransferases ST3GAL1 and ST3GAL4 and modulate mucin 10 glycosylation in the submandibular gland, related to sex differences in …

M Deminami, M Hashimoto, H Takahashi… - Bioscience …, 2025 - academic.oup.com
Sex differences exist in the commensal microbiota that impact on multiple physiological
processes in the host. Here, we examined the mechanism by which the sex differences are …

[HTML][HTML] Genetic Risk Profiling Reveals Altered Glycosyltransferase Expression as a Predictor for Patient Outcome in Neuroblastoma

IA Bley, S Behrens, M Spohn, I Müller… - Journal of Clinical …, 2025 - mdpi.com
Background/Objectives: Neuroblastoma is a highly aggressive pediatric cancer that arises
from immature nerve cells and exhibits a broad spectrum of clinical presentations. While low …

The glycosylation landscape of prostate cancer tissues and biofluids

J Hartig, LEA Young, G Grimsley… - Advances in Cancer …, 2024 - profiles.wustl.edu
An overview of the role of glycosylation in prostate cancer (PCa) development and
progression is presented, focusing on recent advancements in defining the N-glycome …