[HTML][HTML] The role of selenium in pathologies: an updated review

G Barchielli, A Capperucci, D Tanini - Antioxidants, 2022 - mdpi.com
Selenium is an essential microelement required for a number of biological functions.
Selenium—and more specifically the amino acid selenocysteine—is present in at least 25 …

Selenium-dependent antioxidant enzymes: Actions and properties of selenoproteins

E Zoidis, I Seremelis, N Kontopoulos, GP Danezis - Antioxidants, 2018 - mdpi.com
Unlike other essential trace elements that interact with proteins in the form of cofactors,
selenium (Se) becomes co-translationally incorporated into the polypeptide chain as part of …

Selenoproteins: molecular pathways and physiological roles

VM Labunskyy, DL Hatfield… - Physiological …, 2014 - journals.physiology.org
Selenium is an essential micronutrient with important functions in human health and
relevance to several pathophysiological conditions. The biological effects of selenium are …

Selenium biochemistry and its role for human health

M Roman, P Jitaru, C Barbante - Metallomics, 2014 - academic.oup.com
Despite its very low level in humans, selenium plays an important and unique role among
the (semi) metal trace essential elements because it is the only one for which incorporation …

Role of selenoproteins in redox regulation of signaling and the antioxidant system: a review

Y Zhang, YJ Roh, SJ Han, I Park, HM Lee, YS Ok… - Antioxidants, 2020 - mdpi.com
Selenium is a vital trace element present as selenocysteine (Sec) in proteins that are, thus,
known as selenoproteins. Humans have 25 selenoproteins, most of which are functionally …

Selenium and its supplementation in cardiovascular disease—what do we know?

C Benstoem, A Goetzenich, S Kraemer, S Borosch… - Nutrients, 2015 - mdpi.com
The trace element selenium is of high importance for many of the body's regulatory and
metabolic functions. Balanced selenium levels are essential, whereas dysregulation can …

Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after the discovery

D Vaudry, A Falluel-Morel, S Bourgault, M Basille… - Pharmacological …, 2009 - ASPET
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 38-amino acid C-terminally
α-amidated peptide that was first isolated 20 years ago from an ovine hypothalamic extract …

Importance of selenium and selenoprotein for brain function: From antioxidant protection to neuronal signalling

ND Solovyev - Journal of inorganic biochemistry, 2015 - Elsevier
Multiple biological functions of selenium manifest themselves mainly via 25 selenoproteins
that have selenocysteine at their active centre. Selenium is vital for the brain and seems to …

Rethinking mercury: the role of selenium in the pathophysiology of mercury toxicity

HA Spiller - Clinical toxicology, 2018 - Taylor & Francis
Introduction: There is increasing evidence that the pathophysiological target of mercury is in
fact selenium, rather than the covalent binding of mercury to sulfur in the body's ubiquitous …

The human selenoproteome: recent insights into functions and regulation

MA Reeves, PR Hoffmann - Cellular and molecular life sciences, 2009 - Springer
Selenium (Se) is a nutritional trace mineral essential for various aspects of human health
that exerts its effects mainly through its incorporation into selenoproteins as the amino acid …