Protein–protein interactions (PPIs) are involved at all levels of cellular organization, thus
making the development of PPI inhibitors extremely valuable. The identification of selective …

Inhibition of protein–protein interactions (PPIs) represents a significant challenge because it
is unclear how they can be effectively and selectively targeted using small molecules …

The past several decades have witnessed great progress in the understanding of the high-
order structure of biomacromolecules. Currently, it is well-recognized that folding of proteins …

In recent years, significant effort has gone into making synthetic oligomers that can attain
well-defined conformations analogous to the folding of biomolecules. The diversity of the …

Many biological processes are regulated by protein–protein interactions (PPIs) and as such
their misregulation can cause a multitude of diseases. Often the interactions between large …

Chemical sensing of amino acids, peptides, and proteins provides fruitful information to
understand their biological functions, as well as to develop the medical and technological …

The growth of advanced prostate cancer depends on androgen receptor signalling, however
treatment options are limited. Here we report the disruption of specific protein–protein …

The development of small molecules that can modulate the damaging effects of protein
aggregation processes remains a high priority goal in contemporary medicinal chemistry.[1] …

Here, we report that wild type Escherichia coli ribosomes accept and elongate precharged
initiator tRNAs acylated with multiple benzoic acids, including aramid precursors, as well as …

Protein–protein interactions (PPIs) play a central role in virtually all biological processes and
have been the focus of intense investigation from structural molecular biology to cell biology …