For many retinal diseases, including age-related macular degeneration (AMD), glaucoma,
and diabetic retinopathy (DR), the exact pathogenesis is still unclear. Moreover, the currently …

Advances in human genetics have implicated a growing number of genes in
neurodegenerative diseases, providing insight into pathological processes. For Alzheimer …

Glial cells serve as fundamental regulators of the central nervous system in development,
homeostasis, and disease. Discoveries into the function of these cells have fueled …

Microglia are the main resident immune cells of the nervous system and as such they are
involved in multiple roles ranging from tissue homeostasis to response to insults and circuit …

It has recently emerged that microglia, the tissue-resident macrophages of the central
nervous system, play significant non-innate immune roles to support the development …

The eye is an immune privileged tissue that insulates the visual system from local and
systemic immune provocation to preserve homeostatic functions of highly specialized retinal …

Local blood flow control within the central nervous system (CNS) is critical to proper function
and is dependent on coordination between neurons, glia, and blood vessels. Macroglia …

Inherited retinal degeneration (RD) leads to the impairment or loss of vision in millions of
individuals worldwide, most frequently due to the loss of photoreceptor (PR) cells. Animal …

There are several cellular and acellular structural barriers associated with the brain
interfaces, which include the dura, the leptomeninges, the perivascular space and the …

Retinitis pigmentosa (RP) is an important cause of irreversible blindness worldwide and
lacks effective treatment strategies. Although mutations are the primary cause of RP …