Microglia, the resident immune cells of the central nervous system, mediate brain
homeostasis by controlling neuronal proliferation/differentiation and synaptic activity. In …

Recent years have yielded significant advances in our understanding of microglia, the
immune cells of the central nervous system (CNS). Microglia are key players in CNS …

The lack of effective treatment for neurological disorders has encouraged the search for
novel therapeutic strategies. Remarkably, neuroinflammation provoked by the activated …

Cannabinoids are increasingly-used substances in the treatment of chronic pain, some
neuropsychiatric disorders and more recently, skin disorders with an inflammatory …

Multiple sclerosis (MS) is the most common chronic autoimmune disease of the central
nervous system. Efficacy of treatments for MS is associated with risk of adverse effects, and …

Background Traumatic brain injury (TBI) is characterized by a primary mechanical injury and
a secondary injury associated with neuroinflammation, blood–brain barrier (BBB) disruption …

Over evolution, some amino-acid catabolic pathways have become critical checkpoints in
immunity (1–3). The associated immunoregulatory effects rely on the depletion of specific …

Over the past 50 years, intense research effort has taught us a great deal about multiple
sclerosis. We know that it is the most common neurological disease affecting the young …

Oxygen is both vital and toxic to life. Molecular oxygen is the most used substrate in the
human body and is required for several hundred diverse biochemical reactions. The …

Theiler's murine encephalomyelitis virus (TMEV), a naturally occurring, enteric pathogen of
mice is a Cardiovirus of the Picornaviridae family. Low neurovirulent TMEV strains such as …