Advances in pathogenesis and therapeutic strategies for osteoporosis

S Song, Y Guo, Y Yang, D Fu - Pharmacology & therapeutics, 2022 - Elsevier
Osteoporosis, is the most common bone disorder worldwide characterized by low bone
mineral density, leaving affected bones vulnerable to fracture. Bone homeostasis depends …

[HTML][HTML] Bacillus subtilis-Based Probiotic Improves Skeletal Health and Immunity in Broiler Chickens Exposed to Heat Stress

S Jiang, FF Yan, JY Hu, A Mohammed, HW Cheng - Animals, 2021 - mdpi.com
Simple Summary High ambient temperature is a major environmental stressor affecting the
physiological and behavioral status of animals, increasing stress susceptibility and …

Lactobacillus rhamnosus GG ameliorates osteoporosis in ovariectomized rats by regulating the Th17/Treg balance and gut microbiota structure

M Guo, H Liu, Y Yu, X Zhu, H Xie, C Wei, C Mei… - Gut …, 2023 - Taylor & Francis
Background With increasing knowledge about the gut–bone axis, more studies for
treatments based on the regulation of postmenopausal osteoporosis by gut microbes are …

[HTML][HTML] Bifidobacterium longum Ameliorates Ovariectomy-Induced Bone Loss via Enhancing Anti-Osteoclastogenic and Immunomodulatory Potential of Regulatory …

L Sapra, N Shokeen, K Porwal, C Saini… - Frontiers in …, 2022 - frontiersin.org
Discoveries in the last few years have emphasized the existence of an enormous breadth of
communication between osteo-immune systems. These discoveries fuel novel approaches …

[HTML][HTML] Long-term implications of COVID-19 on bone health: pathophysiology and therapeutics

L Sapra, C Saini, B Garg, R Gupta, B Verma… - Inflammation …, 2022 - Springer
Background SARS-CoV-2 is a highly infectious respiratory virus associated with coronavirus
disease (COVID-19). Discoveries in the field revealed that inflammatory conditions exert a …

The rising era of “Immunoporosis”: Role of immune system in the pathophysiology of osteoporosis

RK Srivastava, L Sapra - Journal of Inflammation Research, 2022 - Taylor & Francis
Discoveries in the last few years have emphasized the existence of an enormous breadth of
communication between bone and the immune system in maintaining skeletal homeostasis …

[HTML][HTML] Modulatory effect of gut microbiota on the gut-brain, gut-bone axes, and the impact of cannabinoids

I Ibrahim, S Syamala, JA Ayariga, J Xu, BK Robertson… - Metabolites, 2022 - mdpi.com
The gut microbiome is a collection of microorganisms and parasites in the gastrointestinal
tract. Many factors can affect this community's composition, such as age, sex, diet …

Targeting chronic inflammation as a potential adjuvant therapy for osteoporosis

G Livshits, A Kalinkovich - Life Sciences, 2022 - Elsevier
Systemic, chronic, low-grade inflammation (SCLGI) underlies the pathogenesis of various
widespread diseases. It is often associated with bone loss, thus connecting chronic …

[HTML][HTML] Increased frequency of Th17 cells and IL-17 levels are associated with low bone mineral density in postmenopausal women

H Bhadricha, V Patel, AK Singh, L Savardekar… - Scientific Reports, 2021 - nature.com
Osteoporosis is one of the chronic and often neglected bone diseases in aging
postmenopausal women that affect the quality of life. Studies on ovariectomized mice …

Crosstalk between the gut microbiota and postmenopausal osteoporosis: Mechanisms and applications

Q Xu, D Li, J Chen, J Yang, J Yan, Y Xia… - International …, 2022 - Elsevier
Postmenopausal osteoporosis (PMO) results from a reduction in bone mass and
microarchitectural deterioration in bone tissue due to estrogen deficiency, which may …