Metabolomics in the study of retinal health and disease

I Laíns, M Gantner, S Murinello, JA Lasky-Su… - Progress in retinal and …, 2019 - Elsevier
Metabolomics is the qualitative and quantitative assessment of the metabolites (small
molecules< 1.5 kDa) in body fluids. The metabolites are the downstream of the genetic …

Omics in myopia

ET Grochowski, K Pietrowska, T Kowalczyk… - Journal of Clinical …, 2020 - mdpi.com
Myopia is a globally emerging issue, with multiple medical and socio-economic burdens and
no well-established causal treatment thus far. A better insight into altered biochemical …

Monitoring retinoblastoma by machine learning of aqueous humor metabolic fingerprinting

W Liu, Y Luo, J Dai, L Yang, L Huang, R Wang… - Small …, 2022 - Wiley Online Library
The most common intraocular pediatric malignancy, retinoblastoma (RB), accounts for≈
10% of cancer in children. Efficient monitoring can enhance living quality of patients and 5 …

Metabolomic profiling of aqueous humor in glaucoma points to taurine and spermine deficiency: findings from the eye-D study

A Buisset, P Gohier, S Leruez, J Muller… - Journal of proteome …, 2019 - ACS Publications
We compared the metabolomic profile of aqueous humor from patients with primary open-
angle glaucoma (POAG; n= 26) with that of a group of age-and sex-matched non-POAG …

Quantitative metabolomic analysis of changes in the lens and aqueous humor under development of age-related nuclear cataract

VV Yanshole, LV Yanshole, OA Snytnikova… - Metabolomics, 2019 - Springer
Introduction Metabolites are essential for the proper functioning of the eye lens, they either
enter the lens from the aqueous humor (AH), or are synthesized in the lens epithelium …

An exploratory LC‐MS‐based metabolomics study reveals differences in aqueous humor composition between diabetic and non‐diabetic patients with cataract

K Pietrowska, DA Dmuchowska, P Krasnicki… - …, 2018 - Wiley Online Library
Cataract is the leading cause of blindness worldwide. Epidemiological studies revealed up
to a fivefold increased prevalence of cataracts in diabetic subjects. Metabolomics is …

Metabolomics reveals differences in aqueous humor composition in patients with and without pseudoexfoliation syndrome

DA Dmuchowska, K Pietrowska, P Krasnicki… - Frontiers in Molecular …, 2021 - frontiersin.org
Pseudoexfoliation syndrome (XFS) is stress-or inflammation-induced elastosis accompanied
by excessive production of microfibrils and their deposition in the anterior segment of the …

Analysis of pharmaceuticals and small molecules in aqueous humor

K Pietrowska, DA Dmuchowska, P Krasnicki… - … of pharmaceutical and …, 2018 - Elsevier
Aqueous humor (AH) is a transparent fluid found in the anterior chamber of the eye. The
circulating AH nourishes the cornea and lens and removes the metabolic waste moving …

Proteomic characterization of aqueous humor in corneal endothelial decompensation after penetrating keratoplasty

P Peng, Y Yu, W Ma, S Lyu, L Ma, T Liu, Y Dong… - Experimental eye …, 2023 - Elsevier
Corneal endothelial decompensation (CED) is the major cause of the long-term graft failure,
but the underlying mechanisms remain unclear. The purpose of this study was to …

Hippocampal Sector–Specific Metabolic Profiles Reflect Endogenous Strategy for Ischemia-Reperfusion Insult Resistance

O Krupska, T Kowalczyk, M Beręsewicz-Haller… - Molecular …, 2021 - Springer
The gerbil is a well-known model for studying cerebral ischemia. The CA1 of the
hippocampus is vulnerable to 5 min of ischemia, while the CA2–4 and dentate gyrus (DG) …