Idiopathic nephrotic syndrome newly affects 1–3 per 100,000 children per year.
Approximately 85% of cases show complete remission of proteinuria following …

The use of the calcineurin inhibitors cyclosporine and tacrolimus led to major advances in
the field of transplantation, with excellent short-term outcome. However, the chronic …

Abstract Model-informed precision dosing (MIPD) stands as a significant development in
personalized medicine to tailor drug dosing to individual patient characteristics. MIPD moves …

Tacrolimus (FK506) and cyclosporine (cyclosporin A, CsA) are cornerstone
immunosuppressive agents administered to solid organ transplant recipients to prevent and …

Background: There is no doubt that acute calcineurin inhibitor (CNI) nephrotoxicity exists;
however, chronic CNI nephrotoxicity is questionable at best. Methods: We reviewed the …

Although therapeutic drug monitoring (TDM) of immunosuppressive drugs has been an
integral part of routine clinical practice in solid organ transplantation for many years …

Significant advancements in solid organ transplantation immunosuppressive medications
and regimens have resulted in improved outcomes over the years. A multidrug approach …

Background. Reducing immunosuppression is the treatment of choice for polyomavirus-
associated nephropathy in kidney transplant (KT) patients, but strategies and targets are …

The transplantation literature includes numerous papers that report associations between
polymorphisms in genes encoding metabolizing enzymes and drug transporters, and …

Introduction Circadian rhythm influences the pharmacokinetics and pharmacodynamics of a
number of drugs and affects their therapeutic efficacy and toxicity depending on the time of …