Heart failure (HF) is marked by distinctive changes in myocardial uptake and utilization of
energy substrates. Among the different types of HF, HF with preserved ejection fraction …

Mitochondria are key orchestrators of antiviral responses that serve as platforms for the
assembly and activation of innate immune-signaling complexes. In response to viral …

Aging results in significant loss of mass and function of the skeletal muscle, which negatively
impacts the quality of life. In this study we investigated whether aerobic exercise training has …

Superoxide dismutases (SODs) belong to a significant and ubiquitous family of
metalloenzymes for eliminating excess reactive oxygen species (ROS). In this paper, the …

Diurnal oscillations in the expression of antioxidant genes imply that protection against
oxidative stress is circadian-gated. We hypothesized that stabilization of the core circadian …

The transcriptional regulation of peroxisome proliferator-activated receptor (PPAR) α by post-
translational modification, such as ubiquitin, has not been described. We report here for the …

This study investigated modifications to the ubiquitin proteasome system (UPS) in a mouse
model of type 2 diabetes mellitus (T2DM) and their relationship to heart complications. db/db …

The muscle RING-finger protein-1 (MuRF1) is an E3 ubiquitin ligase expressed in skeletal
and cardiac muscle tissues and it plays important roles in muscle remodeling. Upregulation …

We have previously found that Epigallocatechin-3-gallate (EGCg), an abundant catechin in
green tea, reduced apoptotic signaling and improved muscle recovery in response to …

Androgen-deficiency promotes muscle atrophy in part by increasing autophagy-mediated
muscle protein breakdown during the fasted state, but factors contributing to this remain …