The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that controls
the expression of a diverse set of genes. The toxicity of the potent AhR ligand 2, 3, 7, 8 …

Estrogens are eliminated from the body by metabolic conversion to estrogenically inactive
metabolites that are excreted in the urine and/or feces. The first step in the metabolism of …

With contributions from more than 75 international experts, this second edition focuses on
toxic substances and how they affect ecosystems worldwide. It presents methods for …

Background An array of environmental compounds is known to possess endocrine
disruption (ED) potentials. Bisphenol A (BPA) and bisphenol A dimethacrylate (BPA-DM) are …

Background: The aryl hydrocarbon receptor (AhR or dioxin receptor) is a ligand‐activated
transcription factor that is considered to mediate pleiotropic biological responses such as …

The third Canadian Arctic Human Health Assessment conducted under the Canadian
Northern Contaminants Program (NCP), in association with the circumpolar Arctic …

Members of the nuclear-receptor superfamily mediate crucial physiological functions by
regulating the synthesis of their target genes. Nuclear receptors are usually activated by …

Polychlorinated biphenyls (PCBs) are ubiquitous environmental persistent contaminants
giving rise to potential health hazard. Some PCBs exert dioxin-like activities mediated …

2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) and structurally related halogenated aromatic
compounds are industrial chemicals and combustion byproducts that have been identified in …

The aryl hydrocarbon receptor (Ah receptor or AHR) is a ligand-activated transcription factor
involved in the regulation of several genes, including those for xenobiotic-metabolizing …