Insights into the biochemical and biophysical mechanisms mediating the longevity of the transparent optics of the eye lens

RA Quinlan, JI Clark - Journal of Biological Chemistry, 2022 - ASBMB
In the human eye, a transparent cornea and lens combine to form the" refracton" to focus
images on the retina. This requires the refracton to have a high refractive index" n," mediated …

[HTML][HTML] Biomechanics of the human lens and accommodative system: Functional relevance to physiological states

K Wang, BK Pierscionek - Progress in retinal and eye research, 2019 - Elsevier
The ability of the human lens to accommodate is mediated by the ciliary muscle and zonule;
the manifest optical power changes depend on the shape and material properties of the …

Structure of the lens and its associations with the visual quality

X Ruan, Z Liu, L Luo, Y Liu - BMJ Open Ophthalmology, 2020 - bmjophth.bmj.com
In humans, the lens is the organ with the ability to change morphology and refractive power,
designated as accommodation, to focus light from various distances and obtain clear retinal …

A validated finite element model to reproduce Helmholtz's theory of accommodation: a powerful tool to investigate presbyopia

I Cabeza‐Gil, J Grasa, B Calvo - Ophthalmic and Physiological …, 2021 - Wiley Online Library
Purpose To reproduce human in vivo accommodation numerically. For that purpose, a finite
element model specific for a 29‐year‐old subject was designed. Once the proposed …

A numerical investigation of changes in lens shape during accommodation

I Cabeza-Gil, J Grasa, B Calvo - Scientific Reports, 2021 - nature.com
The purpose of this study was to investigate how the mechanical properties and geometry of
the lens influence the changes in lens shape during accommodation. To do so, ex vivo …

The major influence of anterior and equatorial zonular fibres on the far-to-near accommodation revealed by a 3D pre-stressed model of the anterior eye

Y Pu, Z Liu, L Ye, Y Xia, X Chen, K Wang… - Computer Methods and …, 2023 - Elsevier
Purpose To explore the synergistic function of the ligaments in eye, the zonular fibres, that
mediate change in eye lens shape to allow for focussing over different distances. Methods A …

A modeling approach for investigating opto-mechanical relationships in the human eye lens

K Wang, DT Venetsanos, M Hoshino… - IEEE Transactions …, 2019 - ieeexplore.ieee.org
Objective: The human visual system alters its focus by a shape change of the eye lens. The
extent to which the lens can adjust ocular refractive power is dependent to a significant …

Characterization of mechanical stress in the occurrence of cortical opacification in age-related cataracts using three-dimensional finite element model of the human …

L Chen, Z Chen, S Hao, R Chen, S Chen, Y Gu… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Cataract is the leading cause of blindness across the world. Age-related cataract (ARC) is
the most common type of cataract, but its pathogenesis is not fully understood. Using three …

The importance of parameter choice in modelling dynamics of the eye lens

K Wang, DT Venetsanos, J Wang, AT Augousti… - Scientific Reports, 2017 - nature.com
The lens provides refractive power to the eye and is capable of altering ocular focus in
response to visual demand. This capacity diminishes with age. Current biomedical …

Influence of anterior capsulorhexis shape, centration, size, and location on intraocular lens position: finite element model

T Rossi, A Ceccacci, G Testa, A Ruggiero… - Journal of Cataract & …, 2022 - journals.lww.com
Purpose: To evaluate the influence of anterior capsulorhexis shape, dimension, and
eccentricity on intraocular lens (IOL) position. Setting: Laboratory investigation. Design …