Sec1/Munc18 (SM) family proteins are essential for every vesicle fusion pathway. The best-
characterized SM protein is the synaptic factor Munc18-1, but it remains unclear whether its …

Abstract The Arabidopsis thaliana Qa-SNARE SYP121 (= SYR1/PEN1) drives vesicle traffic
at the plasma membrane of cells throughout the vegetative plant. It facilitates responses to …

Insulin-stimulated glucose uptake in skeletal muscle is of fundamental importance to prevent
postprandial hyperglycemia, and long-term deficits in insulin-stimulated glucose uptake …

Insulin stimulates glucose transport into fat and muscle cells by increasing the exocytic
trafficking rate of the GLUT4 facilitative glucose transporter from intracellular stores to the …

OBJECTIVE Our previous studies suggest that the SNARE protein synaptosomal-associated
protein of 23 kDa (SNAP23) is involved in the link between increased lipid levels and insulin …

Insulin resistance, a hallmark of impaired glucose tolerance and type 2 diabetes (T2D),
arises from dysfunction of insulin action and subsequent glucose uptake by peripheral …

Intracellular vesicle fusion requires the soluble N-ethylmaleimide-sensitive factor attachment
protein receptors (SNAREs) and their cognate Sec1/Munc18 (SM) proteins. How SM …

The fusion of GLUT4-containing vesicles with the plasma membrane of adipocytes is a key
facet of insulin action. This process is mediated by the formation of functional soluble N …

Background Insulin stimulates exocytosis of GLUT4 from an intracellular store to the cell
surface of fat and muscle cells. Fusion of GLUT4-containing vesicles with the plasma …

Insulin stimulates glucose transport in fat and muscle cells by regulating delivery of the
facilitative glucose transporter, glucose transporter isoform 4 (GLUT4), to the plasma …