The reprogramming of somatic cells with defined factors, which converts cells from one
lineage into cells of another, has greatly reshaped our traditional views on cell identity and …

Spinal cord injury (SCI), for which there currently is no cure, is a heavy burden on patient
physiology and psychology. The microenvironment of the injured spinal cord is complicated …

In vivo cell fate conversions have emerged as potential regeneration-based therapeutics for
injury and disease. Recent studies reported that ectopic expression or knockdown of certain …

Conversion of glial cells into functional neurons represents a potential therapeutic approach
for replenishing neuronal loss associated with neurodegenerative diseases and brain injury …

Adult mammalian brains have largely lost neuroregeneration capability except for a few
niches. Previous studies have converted glial cells into neurons, but the total number of …

Adult neurogenesis plays critical roles in maintaining brain homeostasis and responding to
neurogenic insults. However, the adult mammalian spinal cord lacks an intrinsic capacity for …

Despite the widespread interest in direct neuronal reprogramming, the mechanisms
underpinning fate conversion remain largely unknown. Our study revealed a critical time …

It is critical for the clinical success to take the anti-inflammatory function into consideration
when integrating the neurogenesis into the nerve repair materials. To this aim, we prepared …

Lineage reprogramming of resident glial cells to dopaminergic neurons (DAns) is an
attractive prospect of the cell-replacement therapy for Parkinson's disease (PD). However, it …

Reprogramming brain-resident glial cells into clinically relevant induced neurons (iNs) is an
emerging strategy toward replacing lost neurons and restoring lost brain functions. A …