Aflatoxins: History, significant milestones, recent data on their toxicity and ways to mitigation

D Pickova, V Ostry, J Toman, F Malir - Toxins, 2021 - mdpi.com
In the early 1960s the discovery of aflatoxins began when a total of 100,000 turkey poults
died by hitherto unknown turkey “X” disease in England. The disease was associated with …

Public health impacts of foodborne mycotoxins

F Wu, JD Groopman, JJ Pestka - Annual review of food science …, 2014 - annualreviews.org
Mycotoxins are toxic and carcinogenic metabolites produced by fungi that colonize food
crops. The most agriculturally important mycotoxins known today are aflatoxins, which cause …

Risk assessment of aflatoxins in food

EFSA Panel on Contaminants in the Food Chain … - EFSA …, 2020 - Wiley Online Library
EFSA was asked to deliver a scientific opinion on the risks to public health related to the
presence of aflatoxins in food. The risk assessment was confined to aflatoxin B1 (AFB 1) …

Risk assessment of ochratoxin A in food

EFSA Panel on Contaminants in the Food Chain … - EFSA …, 2020 - Wiley Online Library
Abstract The European Commission asked EFSA to update their 2006 opinion on ochratoxin
A (OTA) in food. OTA is produced by fungi of the genus Aspergillus and Penicillium and …

Toxicity, metabolism, and impact of mycotoxins on humans and animals

HS Hussein, JM Brasel - Toxicology, 2001 - Elsevier
The worldwide contamination of foods and feeds with mycotoxins is a significant problem.
Mycotoxins are secondary metabolites of molds that have adverse effects on humans …

Aflatoxin: a 50-year odyssey of mechanistic and translational toxicology

TW Kensler, BD Roebuck, GN Wogan… - Toxicological …, 2011 - academic.oup.com
Since their discovery 50 years ago, the aflatoxins have become recognized as ubiquitous
contaminants of the human food supply throughout the economically developing world. The …

Mycotoxin biomarkers of exposure: A comprehensive review

A Vidal, M Mengelers, S Yang… - … Reviews in Food …, 2018 - Wiley Online Library
To date, the use of biomarkers has become generally accepted. Biomarker‐driven research
has been proposed as a successful method to assess the exposure to xenobiotics by using …

Aflatoxin B1 metabolism: Regulation by phase I and II metabolizing enzymes and chemoprotective agents

J Deng, L Zhao, NY Zhang, NA Karrow… - … research/reviews in …, 2018 - Elsevier
Abstract Aflatoxin B 1 (AFB 1) widely contaminates staple food and feed crops and is well-
known as the most potent natural hepatocarcinogen in humans and domesticated animals …

A follow-up study of urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, People's Republic of China.

GS Qian, RK Ross, MC Yu, JM Yuan, YT Gao… - … , biomarkers & prevention …, 1994 - AACR
A cohort of 18,244 mostly middle-aged (45-64 years) men residing in four small
geographically defined areas of Shanghai was accrued between January 1986 and …

Urinary aflatoxin biomarkers and risk of hepatocellular carcinoma

RK Ross, MC Yu, BE Henderson, JM Yuan, GS Qian… - The Lancet, 1992 - Elsevier
Aflatoxins have long been suspected to be human hepatic carcinogens but no direct study
was feasible until assays to measure individual aflatoxin exposure became available. We …