How to turn an organism into a model organism in 10 'easy'steps
BJ Matthews, LB Vosshall - Journal of Experimental Biology, 2020 - journals.biologists.com
Many of the major biological discoveries of the 20th century were made using just six
species: Escherichia coli bacteria, Saccharomyces cerevisiae and Schizosaccharomyces …
species: Escherichia coli bacteria, Saccharomyces cerevisiae and Schizosaccharomyces …
PIWIs go viral: arbovirus-derived piRNAs in vector mosquitoes
P Miesen, J Joosten, RP van Rij - PLoS pathogens, 2016 - journals.plos.org
Vector mosquitoes are responsible for transmission of the majority of arthropod-borne (arbo-
) viruses. Virus replication in these vectors needs to be sufficiently high to permit efficient …
) viruses. Virus replication in these vectors needs to be sufficiently high to permit efficient …
Improved reference genome of Aedes aegypti informs arbovirus vector control
Female Aedes aegypti mosquitoes infect more than 400 million people each year with
dangerous viral pathogens including dengue, yellow fever, Zika and chikungunya. Progress …
dangerous viral pathogens including dengue, yellow fever, Zika and chikungunya. Progress …
A male-determining factor in the mosquito Aedes aegypti
Sex determination in the mosquito Aedes aegypti is governed by a dominant male-
determining factor (M factor) located within a Y chromosome–like region called the M locus …
determining factor (M factor) located within a Y chromosome–like region called the M locus …
Transforming insect population control with precision guided sterile males with demonstration in flies
The sterile insect technique (SIT) is an environmentally safe and proven technology to
suppress wild populations. To further advance its utility, a novel CRISPR-based technology …
suppress wild populations. To further advance its utility, a novel CRISPR-based technology …
A transcriptomic atlas of Aedes aegypti reveals detailed functional organization of major body parts and gut regional specializations in sugar-fed and blood-fed adult …
Mosquitoes transmit numerous pathogens, but large gaps remain in our understanding of
their physiology. To facilitate explorations of mosquito biology, we have created Aegypti …
their physiology. To facilitate explorations of mosquito biology, we have created Aegypti …
Germline Cas9 expression yields highly efficient genome engineering in a major worldwide disease vector, Aedes aegypti
The development of CRISPR/Cas9 technologies has dramatically increased the accessibility
and efficiency of genome editing in many organisms. In general, in vivo germline expression …
and efficiency of genome editing in many organisms. In general, in vivo germline expression …
Non-retroviral endogenous viral element limits cognate virus replication in Aedes aegypti ovaries
Endogenous viral elements (EVEs) are viral sequences integrated in host genomes. A large
number of non-retroviral EVEs was recently detected in Aedes mosquito genomes, leading …
number of non-retroviral EVEs was recently detected in Aedes mosquito genomes, leading …
Distinct sets of PIWI proteins produce arbovirus and transposon-derived piRNAs in Aedes aegypti mosquito cells
Abstract The PIWI-interacting RNA (piRNA) pathway is essential for transposon silencing in
many model organisms. Its remarkable efficiency relies on a sophisticated amplification …
many model organisms. Its remarkable efficiency relies on a sophisticated amplification …
The diversity, structure, and function of heritable adaptive immunity sequences in the Aedes aegypti genome
The Aedes aegypti mosquito transmits arboviruses, including dengue, chikungunya, and
Zika virus. Understanding the mechanisms underlying mosquito immunity could provide new …
Zika virus. Understanding the mechanisms underlying mosquito immunity could provide new …