The dynamics, distribution and activity of subcellular organelles are integral to regulating
cell shape changes during various physiological processes such as epithelial cell formation …

Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are
neurodegenerative disorders characterized by declining motor and cognitive functions. Even …

Much is known about the factors involved in the translation of messenger RNA (mRNA) into
protein; however, this multistep process has not been imaged in living multicellular …

Growth of the Drosophila oocyte requires transport of cytoplasmic materials from the
interconnected sister cells (nurse cells) through ring canals, the cytoplasmic bridges that …

Diet may be modified seasonally or by biogeographic, demographic or cultural shifts. It can
differentially influence mitochondrial bioenergetics, retrograde signalling to the nuclear …

Cell and tissue functions rely on the genetic programmes and cascades of biochemical
signals. It has become evident during the past decade that the physical properties of soft …

Cell-intrinsic and extrinsic signals regulate the state and fate of stem and progenitor cells.
Recent advances in metabolomics illustrate that various metabolic pathways are also …

Iron sulfur (Fe-S) clusters and the molybdenum cofactor (Moco) are present at enzyme sites,
where the active metal facilitates electron transfer. Such enzyme systems are soluble in the …

An instructive role for metabolism in embryonic patterning is emerging, although a role for
mitochondria is poorly defined. We demonstrate that mitochondrial oxidative metabolism …

Cytoplasmic dynein, a major minus-end directed microtubule motor, plays essential roles in
eukaryotic cells. Drosophila oocyte growth is mainly dependent on the contribution of …