Epidemiological and interventional human studies, as well as experiments in animal
models, strongly indicate that helminth parasitic infections can confer protection from …

The vertebrate gut teems with a large, diverse, and dynamic bacterial community that has
pervasive effects on gut physiology, metabolism, and immunity. Under natural conditions …

Parasitic nematodes (roundworms) and platyhelminths (flatworms) cause debilitating
chronic infections of humans and animals, decimate crop production and are a major …

In mammalian systems RNA can move between cells via vesicles. Here we demonstrate that
the gastrointestinal nematode Heligmosomoides polygyrus, which infects mice, secretes …

Helminth parasites defy immune exclusion through sophisticated evasion mechanisms,
including activation of host immunosuppressive regulatory T (Treg) cells. The mouse …

The intestinal microbiota are pivotal in determining the developmental, metabolic and
immunological status of the mammalian host. However, the intestinal tract may also …

A characteristic feature of host responses to helminth infections is the development of
profound systemic and tissue-localised Type 2 immune responses that play critical roles in …

Helminth parasites infect an alarmingly large proportion of the world's population, primarily
within tropical regions, and their ability to down‐modulate host immunity is key to their …

Intestinal helminths have well-characterized modulatory effects on mammalian immune
pathways. Ongoing helminth infection has been associated with both the suppression of …

Both intestinal helminth parasites and certain bacterial microbiota species have been
credited with strong immunomodulatory effects. Recent studies reported that the presence of …