Obesity is believed to be a promoter of type 2 diabetes mellitus (T2DM). Reports indicate
that severe obesity in childhood and adolescence increases the risk of T2DM in youth and …

The prevalence of obesity has recently increased dramatically and has contributed to the
increasing prevalence of various pathological conditions, including type 2 diabetes mellitus …

Importance The efficacy and safety of time-restricted eating have not been explored in large
randomized clinical trials. Objective To determine the effect of 16: 8-hour time-restricted …

Summary Although 5%–10% weight loss is routinely recommended for people with obesity,
the precise effects of 5% and further weight loss on metabolic health are unclear. We …

Pancreatic islet transplantation has become an established approach to β-cell replacement
therapy for the treatment of insulin-deficient diabetes. Recent progress in techniques for islet …

Importance The prevalence of obesity and outcomes of bariatric surgery are well
established. However, analyses of the surgery impact have not been updated and …

Weight loss is the cornerstone of therapy for people with obesity because it can ameliorate
or completely resolve the metabolic risk factors for diabetes, coronary artery disease, and …

Incretin peptides, principally GLP-1 and GIP, regulate islet hormone secretion, glucose
concentrations, lipid metabolism, gut motility, appetite and body weight, and immune …

Bariatric surgical procedures, such as vertical sleeve gastrectomy (VSG), are at present the
most effective therapy for the treatment of obesity, and are associated with considerable …

OBJECTIVE: This article examines the foundation of β-cell failure in type 2 diabetes (T2D)
and suggests areas for future research on the underlying mechanisms that may lead to …