The building blocks of life–nucleotides, amino acids and saccharides–give rise to a large
variety of components and make up the hierarchical structures found in Nature. Driven by …

Contemporary drug discovery approaches rely on library synthesis coupled with
combinatorial methods and high-throughput screening to identify leads. However, due to the …

Controlling the self-assembly pathways can be an effective means to create complex
multifunctional structures based on a single gelator design. To this direction, an ion …

Peptidomimetics are a class of compounds with promising pharmacological properties.
Peptidomimetics reduce limitations of peptides including low bioavailability, poor stability …

Ras proteins have been reported to play key role in oncologic diseases. Ras proteins are
associated with cellular membranes for its carcinogenic activities through post-translational …

Molecular dynamics (MD) simulations have been used to characterize the effects of
backbone N-amination of residues in a model β-hairpin peptide. This modification is of …

Solid-phase peptide synthesis (SPPS) is used to create peptidomimetics in which one of the
backbone amide C O bonds is replaced by a four-membered oxetane ring. The oxetane …

Protein-protein interactions (PPIs) are recognized as attractive therapeutic targets. However
targeting PPIs especially intracellular ones has been proven extremely difficult for …

In this work, we have applied the concept of α-hydrazino acid insertion in a peptide
sequence as a means of structurally organizing a potential protein–protein interactions (PPI) …

The chemical modification of peptides is a promising approach for the design of protein-
protein interaction inhibitors and peptide-based drug candidates. Among several …