Ironing out ferroportin

H Drakesmith, E Nemeth, T Ganz - Cell metabolism, 2015 - cell.com
Maintaining physiologic iron concentrations in tissues is critical for metabolism and host
defense. Iron absorption in the duodenum, recycling of iron from senescent erythrocytes …

Iron as a central player and promising target in cancer progression

M Jung, C Mertens, E Tomat, B Brüne - International journal of molecular …, 2019 - mdpi.com
Iron is an essential element for virtually all organisms. On the one hand, it facilitates cell
proliferation and growth. On the other hand, iron may be detrimental due to its redox …

Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms

CB Billesbølle, CM Azumaya, RC Kretsch, AS Powers… - Nature, 2020 - nature.com
The serum level of iron in humans is tightly controlled by the action of the hormone hepcidin
on the iron efflux transporter ferroportin. Hepcidin regulates iron absorption and recycling by …

Systemic iron homeostasis

T Ganz - Physiological reviews, 2013 - journals.physiology.org
The iron hormone hepcidin and its receptor and cellular iron exporter ferroportin control the
major fluxes of iron into blood plasma: intestinal iron absorption, the delivery of recycled iron …

Mechanistic and regulatory aspects of intestinal iron absorption

S Gulec, GJ Anderson… - American Journal of …, 2014 - journals.physiology.org
Iron is an essential trace mineral that plays a number of important physiological roles in
humans, including oxygen transport, energy metabolism, and neurotransmitter synthesis …

Mechanisms of mammalian iron homeostasis

K Pantopoulos, SK Porwal, A Tartakoff… - Biochemistry, 2012 - ACS Publications
Iron is vital for almost all organisms because of its ability to donate and accept electrons with
relative ease. It serves as a cofactor for many proteins and enzymes necessary for oxygen …

Iron homeostasis and organismal aging

RS Zeidan, SM Han, C Leeuwenburgh, R Xiao - Ageing research reviews, 2021 - Elsevier
Iron is indispensable for normal body functions across species because of its critical roles in
red blood cell function and many essential proteins and enzymes required for numerous …

RNF217 regulates iron homeostasis through its E3 ubiquitin ligase activity by modulating ferroportin degradation

L Jiang, J Wang, K Wang, H Wang… - Blood, The Journal …, 2021 - ashpublications.org
Abstract Ferroportin (FPN), the body's sole iron exporter, is essential for maintaining
systemic iron homeostasis. In response to either increased iron or inflammation, hepatocyte …

Hereditary hemochromatosis: pathogenesis, diagnosis, and treatment

A Pietrangelo - Gastroenterology, 2010 - Elsevier
In the late 1800s, hemochromatosis was considered an odd autoptic finding. More than a
century later, it was finally recognized as a hereditary, multi-organ disorder associated with a …

Ferroportin and iron regulation in breast cancer progression and prognosis

ZK Pinnix, LD Miller, W Wang, R D'Agostino Jr… - Science translational …, 2010 - science.org
Ferroportin and hepcidin are critical proteins for the regulation of systemic iron homeostasis.
Ferroportin is the only known mechanism for export of intracellular non–heme-associated …