Obesity is a growing worldwide health problem, affecting many people due to excessive
saturated fat consumption, lack of exercise, or a sedentary lifestyle. Leptin is an adipokine …

Early life stressors display a high universal prevalence and constitute a major public health
problem. Prolonged psychoneurobiological alterations as sequelae of early life stress (ELS) …

The immediate and long-term effects of exposure to early life stress (ELS) have been
documented in humans and animal models. Even relatively brief periods of stress during the …

More than one-third of American adults are obese and statistics are similar worldwide.
Caloric intake and diet composition have large and lasting effects on cognition and emotion …

Animals susceptible to chronic social defeat stress (CSDS) exhibit depression-related
behaviors, with aberrant transcription across several limbic brain regions, most notably in …

Early life adversity (ELA) is associated with increased risk for stress-related disorders later in
life. The link between ELA and risk for psychopathology is well established but the …

Obesity is frequently associated with impairments in the social domain, and stress at puberty
can lead to long-lasting changes in visceral fat deposition and in social behaviors. However …

Adversity in early childhood exerts an enduring impact on mental and physical health,
academic achievement, lifetime productivity, and the probability of interfacing with the …

Suboptimal maternal care is a form of chronic early-life stress (ELS) and a risk factor for
mental illness and behavioral impairments throughout the life span. The amygdala …

Early-life adversity increases the risk for emotional disorders such as depression and
schizophrenia. Anhedonia, thought to be a core feature of these disorders, is provoked by …