Cannabis has been integral to Eurasian civilization for millennia, but a century of prohibition
has limited investigation. With spreading legalization, science is pivoting to study the …

Cannabidiol is a class of non-psychoactive plant cannabinoids derived from cannabis
plants. Currently, Epidiolex (Cannabidiol) has been approved by the FDA for the treatment of …

Synthesis planning programs trained on chemical reaction data can design efficient routes
to new molecules of interest, but are limited in their ability to leverage rare chemical …

Prenylation of natural compounds adds structural diversity, alters biological activity, and
enhances therapeutic potential. Because prenylated compounds often have a low natural …

The US faces an unprecedented surge in fatal drug overdoses. Naloxone, the only antidote
for opiate overdose, competes at the mu opioid receptor (μOR) orthosteric site. Naloxone …

Cannabidiol (CBD), one of the two major active principles present in Cannabis sativa, is
gaining great interest among the scientific community for its pharmaceutical, nutraceutical …

The therapeutic effects of molecules produced by the plant species Cannabis sativa have
since their discovery captured the interest of scientists and society, and have spurred the …

The resorcinol-terpene phytocannabinoid template is a privileged scaffold for the
development of diverse therapeutics targeting the endocannabinoid system. Axially chiral …

Herein we describe an asymmetric synthesis of the pharmacologically relevant natural (−)-
trans-CBD and psychoactive (−)-trans-Δ9-THC, as well as their synthetic cis diastereomers …

A novel synthetic route for making (−)-CBD and its derivatives bearing various C4′-side
chains is developed by a late-stage diversification method. Starting from commercially …