Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein
J Lei, Y Kusov, R Hilgenfeld - Antiviral research, 2018 - Elsevier
The multi-domain non-structural protein 3 (Nsp3) is the largest protein encoded by the
coronavirus (CoV) genome, with an average molecular mass of about 200 kD. Nsp3 is an …
coronavirus (CoV) genome, with an average molecular mass of about 200 kD. Nsp3 is an …
Multiple sclerosis and myelin basic protein: Insights into protein disorder and disease
V Martinsen, P Kursula - Amino Acids, 2022 - Springer
Myelin basic protein (MBP) is an abundant protein in central nervous system (CNS) myelin.
MBP has long been studied as a factor in the pathogenesis of the autoimmune …
MBP has long been studied as a factor in the pathogenesis of the autoimmune …
[HTML][HTML] Structural basis of SARS-CoV-2 3CLpro and anti-COVID-19 drug discovery from medicinal plants
The recent pandemic of coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 has
raised global health concerns. The viral 3-chymotrypsin-like cysteine protease (3CL pro) …
raised global health concerns. The viral 3-chymotrypsin-like cysteine protease (3CL pro) …
COVID-19 spike-host cell receptor GRP78 binding site prediction
Objectives Understanding the novel coronavirus (COVID-19) mode of host cell recognition
may help to fight the disease and save lives. The spike protein of coronaviruses is the main …
may help to fight the disease and save lives. The spike protein of coronaviruses is the main …
Structural basis of STING binding with and phosphorylation by TBK1
The invasion of mammalian cytoplasm by microbial DNA from infectious pathogens or by
self DNA from the nucleus or mitochondria represents a danger signal that alerts the host …
self DNA from the nucleus or mitochondria represents a danger signal that alerts the host …
Delicate structural coordination of the Severe Acute Respiratory Syndrome coronavirus Nsp13 upon ATP hydrolysis
Z Jia, L Yan, Z Ren, L Wu, J Wang, J Guo… - Nucleic acids …, 2019 - academic.oup.com
To date, an effective therapeutic treatment that confers strong attenuation toward
coronaviruses (CoVs) remains elusive. Of all the potential drug targets, the helicase of CoVs …
coronaviruses (CoVs) remains elusive. Of all the potential drug targets, the helicase of CoVs …
Phototactic guidance of a tissue-engineered soft-robotic ray
Inspired by the relatively simple morphological blueprint provided by batoid fish such as
stingrays and skates, we created a biohybrid system that enables an artificial animal—a …
stingrays and skates, we created a biohybrid system that enables an artificial animal—a …
Deciphering key features in protein structures with the new ENDscript server
ENDscript 2 is a friendly Web server for extracting and rendering a comprehensive analysis
of primary to quaternary protein structure information in an automated way. This major …
of primary to quaternary protein structure information in an automated way. This major …
Type III CRISPR–Cas systems produce cyclic oligoadenylate second messengers
O Niewoehner, C Garcia-Doval, JT Rostøl, C Berk… - Nature, 2017 - nature.com
In many prokaryotes, type III clustered regularly interspaced short palindromic repeat
(CRISPR)–CRISPR-associated (Cas) systems detect and degrade invasive genetic …
(CRISPR)–CRISPR-associated (Cas) systems detect and degrade invasive genetic …
Structural insights into the molecular mechanism of the m6A writer complex
P Śledź, M Jinek - elife, 2016 - elifesciences.org
Methylation of adenosines at the N6 position (m6A) is a dynamic and abundant
epitranscriptomic mark that regulates critical aspects of eukaryotic RNA metabolism in …
epitranscriptomic mark that regulates critical aspects of eukaryotic RNA metabolism in …