Kunitz domain-containing proteins are ubiquitous serine protease inhibitors with promising
therapeutic potential. They target key proteases involved in major cellular processes such as …

Simple Summary Microparticles (MPs) play a key role in intercellular communication and
mediate many features of cancers by delivering their various biomolecular cargos (including …

Ticks are obligatory blood-feeding ectoparasites, causing blood loss and skin damage in
their hosts. In addition, ticks also transmit a number of various pathogenic microorganisms …

Ticks, particularly hard ticks (Ixodidae), which are among the most important vectors of
dangerous infectious agents, feed on their hosts for extended periods of time. With this …

Animal toxins present high selectivity and specificity for their molecular targets, and have
long been considered as prototypes for developing novel drugs, with some successful …

Ticks are unique hematophagous arthropods and possess an astounding array of salivary
molecules that ensure their unnoticed and prolonged attachment to the host skin …

Nowadays, the relationship between cancer blood coagulation is well established.
Regarding biodiversity and bioprospection, the tick biology has become quite attractive …

Background Cancer has long been associated with thrombosis and many of the standard
chemotherapeutics used to treat cancer are pro-thrombotic. Thus, the identification of novel …

Coagulation factor Xa (fXa) is a particularly attractive target for the development of effective
and safe anticoagulants. In this study, novel 2, 3-dihydroquinazolin-4 (1 H)-one derivatives …

Salivary glands are vital structures responsible for successful tick feeding. The saliva of ticks
contains numerous active molecules that participate in several physiological processes. A …