Type 2 diabetes (T2D) is a common chronic disease whose etiology is known to have a
strong genetic component. Standard genetic approaches, although allowing for the …

Type 1 Diabetes (T1D) is a chronic autoimmune disease characterized by a gradual
destruction of insulin-producing β-cells in the endocrine pancreas due to innate and specific …

Methods Islets isolated from nulliparous mice, mice at different time points of gestation and
mice at day 4 after delivery were analysed using scRNA-seq. Bioinformatics analyses of …

The receptor protein tyrosine phosphatase phogrin primarily localizes to hormone secretory
granules in neuroendocrine cells. Concurrent with glucose-stimulated insulin secretion …

Pancreatic β-cells within the islets of Langerhans respond to rising blood glucose levels by
secreting insulin that stimulates glucose uptake by peripheral tissues to maintain whole …

The potential to treat diabetes by increasing beta-cell mass is driving a major effort to identify
beta-cell mitogens. Demonstration of mitogen activity in human beta cells is frequently …

Erjing prescription (EJP) was an ancient formula that was recorded in the General Medical
Collection of Royal Benevolence of the Song Dynasty. It has been frequently used to treat …

A sensible control of hormone secretion from pancreatic islets requires concerted inter-
cellular communications, but a comprehensive picture of the whole islet interactome is …

The extracellular matrix (ECM) provides an appropriate microenvironment for many kinds of
cells, including pancreatic cells. Collagens are the most abundant components of the ECM …

Age-related macular degeneration (AMD), mainly wet AMD, is the major reason for
nonreversible vision loss worldwide. Choroidal neovascularization (CNV) is a characteristic …