The progress made in our understanding of the pathophysiology and treatment of
congestive heart failure (CHF) would not have been possible without a number of animal …

Infarct scar, a requisite to the rebuilding of necrotic myocardium following myocardial
infarction (MI), has long been considered inert. Earlier morphologic studies suggested …

Heart failure is a major health problem worldwide. In the United States, it represents the
number one hospital discharge diagnosis among elderly persons each year. It appears most …

Heart failure is a global health problem, appearing most commonly in patients with previous
myocardial infarction (MI). Cardiac remodelling, particularly fibrosis, seen in both the …

Background—This study analyzed the regulation and the role of the cardiac steroidogenic
system in myocardial infarction (MI). Methods and Results—Seven days after MI, rats were …

Remodeling of the myocardium is the major mechanism for disability and death in prevalent
cardiovascular diseases such as hypertension, heart failure and myocardial infarction (MI). It …

Cardiac phenotypic modulation and remodeling appear to be involved in the
pathophysiology of cardiac hypertrophy and heart failure. We undertook this study to …

Studies have demonstrated that local angiotensin II (Ang II) generation is enhanced in
repairing kidney and that ACE inhibition or AT1 receptor blockade attenuates renal fibrosis …

Background—Beneficial effects of ACE inhibitors on the heart may be mediated by
decreased cardiac angiotensin II (Ang II) production. Methods and Results—To determine …

Background—Angiotensin II (Ang II) has been implicated in ventricular remodeling after
myocardial infarction (MI), which is an important determinant for prognosis after MI. The aim …