Bacterial attachment to biomaterials is of great interest to the medical and dental field due to
its impact on dental implants, dental prostheses, and others, leading to the need to introduce …

Covalent inhibitors and other types of covalent modalities have seen a revival in the past two
decades, with a variety of new targeted covalent drugs having been approved in recent …

Uropygial gland secretions of birds consist of host and bacteria derived compounds and
play a major sanitary and feather-protective role. Here we report on our microbiome studies …

In recent years, dengue virus (DENV) and Zika virus (ZIKV), both mosquito-borne members
of the Flaviviridae family, have emerged as intercontinental health issues since their vectors …

The reactive functionalities of drugs that engage in covalent interactions with the
enzyme/receptor residue in either a reversible or an irreversible manner are …

Rhodesain is a major cysteine protease of Trypanosoma brucei rhodesiense, a pathogen
causing Human African Trypanosomiasis, and a validated drug target. Recently, we reported …

The evolution and spread of methicillin-resistant Staphylococcus aureus (MRSA) poses a
significant hidden risk to human public health. The majority of antibiotics used clinically have …

This review covers the most recent advances in the development of inhibitors for the
bacterial enzyme sortase A (SrtA). Sortase A (SrtA) is a critical virulence factor, present …

Selective manipulation of the epitranscriptome could be beneficial for the treatment of
cancer and also broaden the understanding of epigenetic inheritance. Inhibitors of the tRNA …

Staphylococcus aureus is the leading cause of hospital-acquired infections. The enzyme
sortase A, present on the cell surface of S. aureus, plays a key role in bacterial virulence …