[HTML][HTML] Understanding long COVID; mitochondrial health and adaptation—old pathways, new problems

AVW Nunn, GW Guy, W Brysch, JD Bell - Biomedicines, 2022 - mdpi.com
Many people infected with the SARS-CoV-2 suffer long-term symptoms, such as “brain fog”,
fatigue and clotting problems. Explanations for “long COVID” include immune imbalance …

Chemical tools for lipid cell biology

C Schultz - Accounts of chemical research, 2023 - ACS Publications
Conspectus Lipids are key components of all organisms. We are well educated in their use
as fuel and their essential role to form membranes. We also know much about their …

[HTML][HTML] Risks and burdens of incident dyslipidaemia in long COVID: a cohort study

E Xu, Y Xie, Z Al-Aly - The Lancet Diabetes & Endocrinology, 2023 - thelancet.com
Background Non-clinical evidence and a few human studies with short follow-ups suggest
increased risk of dyslipidaemia in the post-acute phase of COVID-19 (ie,> 30 days after …

Coronaviral ORF6 protein mediates inter‐organelle contacts and modulates host cell lipid flux for virus production

M Yue, B Hu, J Li, R Chen, Z Yuan, H Xiao… - The EMBO …, 2023 - embopress.org
Lipid droplets (LDs) form inter‐organelle contacts with the endoplasmic reticulum (ER) that
promote their biogenesis, while LD contacts with mitochondria enhance β‐oxidation of …

[HTML][HTML] Therapeutic strategy targeting host lipolysis limits infection by SARS-CoV-2 and influenza A virus

YB Baek, HJ Kwon, M Sharif, J Lim, IC Lee… - … and Targeted Therapy, 2022 - nature.com
The biosynthesis of host lipids and/or lipid droplets (LDs) has been studied extensively as a
putative therapeutic target in diverse viral infections. However, directly targeting the LD …

Bioscreening specific peptide-expressing phage and its application in sensitive dual-mode immunoassay of SARS-CoV-2 spike antigen

S Pang, H Yu, Y Zhang, Y Jiao, Z Zheng, M Wang… - Talanta, 2024 - Elsevier
Biorecognition components with high affinity and selectivity are vital in bioassay to diagnose
and treat epidemic disease. Herein a phage display strategy of combining single …

[HTML][HTML] Dynamic label-free analysis of SARS-CoV-2 infection reveals virus-induced subcellular remodeling

N Saunders, B Monel, N Cayet, L Archetti… - Nature …, 2024 - nature.com
Assessing the impact of SARS-CoV-2 on organelle dynamics allows a better understanding
of the mechanisms of viral replication. We combine label-free holotomographic microscopy …

Pinostrobin from plants and propolis against human coronavirus HCoV-OC43 by modulating host AHR/CYP1A1 pathway and lipid metabolism

L Zhao, L Yao, R Chen, J He, T Lin, S Qiu, G Chen… - Antiviral Research, 2023 - Elsevier
Coronaviruses, as enveloped positive-strand RNA viruses, manipulate host lipid
compositions to enable robust viral replication. Temporal modulation of the host lipid …

[HTML][HTML] Drug repurposing for the treatment of COVID-19: Targeting nafamostat to the lungs by a liposomal delivery system

P Reus, H Guthmann, N Uhlig, M Agbaria… - Journal of Controlled …, 2023 - Elsevier
Despite tremendous global efforts since the beginning of the COVID-19 pandemic, still only
a limited number of prophylactic and therapeutic options are available. Although vaccination …

Lipidomics reveals the significance and mechanism of the cellular ceramide metabolism for rotavirus replication

R Tao, X Cheng, L Gu, J Zhou, X Zhu, X Zhang… - Journal of …, 2024 - Am Soc Microbiol
As one of the most important causative agents of severe gastroenteritis in children, piglets,
and other young animals, species A rotaviruses have adversely impacted both human …