Organic anion-transporting polypeptides or OATPs are central transporters in the disposition
of drugs and other xenobiotics. In addition, they mediate transport of a wide variety of …

Previous studies have described that tumor organoids can capture the diversity of defined
human carcinoma types. Here, we describe conditions for long-term culture of human …

Solute carrier organic anion transporter family member 2A1 (SLCO2A1, also known as PGT,
OATP2A1, PHOAR2, or SLC21A2) is a plasma membrane transporter consisting of 12 …

The present invention relates to peptides, proteins, nucleic acids and cells for use in
immunotherapeutic methods. In particular, the present invention relates to the immuno …

ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C ([C@ H](NC (=
O)[C@ H](C (C) C) NC (= O) CNC (= O)[C@ H](CCC (O)= O) NC (= O)[C@ H](CCCNC (N) …

Facilitated transport is necessitated for large size, charged, and/or hydrophilic drugs to move
across the membrane. The drug transporters in the solute carrier (SLC) superfamily, mainly …

The solute carrier (SLC) superfamily encompasses a large variety of membrane-bound
transporters required to transport a diverse array of substrates over biological membranes …

Neuroblastoma is the most common cancer of infancy and accounts for 15% of all pediatric
oncology deaths. Survival rates of high-risk neuroblastoma remain less than 50%, with …

Background SLCO2A1 encodes a prostaglandin (PG) transporter, and autosomal recessive
pathogenic variants of this gene cause chronic enteropathy associated with SLCO2A1. It is …

The identification of drug transporters expressed in human skin and interindividual
differences in gene expression is important for understanding the role of drug transporters in …