A comprehensive guide to the pharmacologic regulation of angiotensin converting enzyme 2 (ACE2), the SARS-CoV-2 entry receptor
The recent emergence of coronavirus disease-2019 (COVID-19) as a global pandemic has
prompted scientists to address an urgent need for defining mechanisms of disease …
prompted scientists to address an urgent need for defining mechanisms of disease …
Renin‐angiotensin aldosterone system inhibitors and COVID‐19: a systematic review and meta‐analysis revealing critical bias across a body of observational …
J Loader, FC Taylor, E Lampa… - Journal of the American …, 2022 - Am Heart Assoc
Background Renin‐angiotensin aldosterone system (RAAS) inhibitor—COVID‐19 studies,
observational in design, appear to use biased methods that can distort the interaction …
observational in design, appear to use biased methods that can distort the interaction …
Risk factors for hospitalization among persons with COVID-19—Colorado
GM Vahey, E McDonald, K Marshall, SW Martin… - PloS one, 2021 - journals.plos.org
Background Most current evidence on risk factors for hospitalization because of coronavirus
disease 2019 (COVID-19) comes from studies using data abstracted primarily from …
disease 2019 (COVID-19) comes from studies using data abstracted primarily from …
Comparison of infection risks and clinical outcomes in patients with and without SARS‐CoV‐2 lung infection under renin–angiotensin–aldosterone system blockade …
C Chu, S Zeng, AA Hasan, CF Hocher… - British Journal of …, 2021 - Wiley Online Library
Aims Angiotensin‐converting enzyme‐2 (ACE2) is the receptor for SARS‐CoV‐2. Animal
studies suggest that renin–angiotensin–aldosterone system (RAAS) blockers might increase …
studies suggest that renin–angiotensin–aldosterone system (RAAS) blockers might increase …
Cardiovascular health care implications of the COVID-19 pandemic
Z Raisi-Estabragh, MA Mamas - Cardiology Clinics, 2022 - cardiology.theclinics.com
The coronavirus disease 2019 (COVID-19) pandemic has placed immense pressure on
health care services, necessitating reorganization and reprioritization of resources and …
health care services, necessitating reorganization and reprioritization of resources and …
Renin‐angiotensin aldosterone system inhibitors in primary prevention and COVID‐19
Background Considering the widespread risk of collider bias and confounding by indication
in previous research, the associations between renin‐angiotensin aldosterone system …
in previous research, the associations between renin‐angiotensin aldosterone system …
Cardiovascular disease complicating COVID-19 in the elderly
C Dayaramani, J De Leon, AB Reiss - Medicina, 2021 - mdpi.com
SARS-CoV-2, a single-stranded RNA coronavirus, causes an illness known as coronavirus
disease 2019 (COVID-19). The highly transmissible virus gains entry into human cells …
disease 2019 (COVID-19). The highly transmissible virus gains entry into human cells …
Angiotensin-converting enzyme 2: from a vasoactive peptide to the gatekeeper of a global pandemic
The renin–angiotensin system is a complex, coordinated hormonal cascade that plays a
pivotal role in controlling individual cell behaviour and multiple organ functions. ACE2 acts …
pivotal role in controlling individual cell behaviour and multiple organ functions. ACE2 acts …
The effect of angiotensin-converting enzyme levels on COVID-19 susceptibility and severity: a Mendelian randomization study
Background There has been uncertainty about the safety or benefit of angiotensin-
converting enzyme (ACE) inhibitors during the COVID-19 pandemic. We used Mendelian …
converting enzyme (ACE) inhibitors during the COVID-19 pandemic. We used Mendelian …
Update alert 7: risks and impact of angiotensin-converting enzyme inhibitors or angiotensin-receptor blockers on SARS-CoV-2 infection in adults
K Mackey, D Kansagara, K Vela - Annals of Internal Medicine, 2021 - acpjournals.org
We searched MEDLINE (Ovid) weekly from 27 October to 23 November 2020 using the
same search strategy as described in the original review (1). We did not limit the search by …
same search strategy as described in the original review (1). We did not limit the search by …