Mechanisms of metabolic reprogramming in cancer cells supporting enhanced growth and proliferation

C Schiliro, BL Firestein - Cells, 2021 - mdpi.com
Cancer cells alter metabolic processes to sustain their characteristic uncontrolled growth
and proliferation. These metabolic alterations include (1) a shift from oxidative …

Glutamine metabolism in breast cancer and possible therapeutic targets

S Li, H Zeng, J Fan, F Wang, C Xu, Y Li, J Tu… - Biochemical …, 2023 - Elsevier
Cancer is characterized by metabolic reprogramming, which is a hot topic in tumor treatment
research. Cancer cells alter metabolic pathways to promote their growth, and the common …

Reprogramming of lipid metabolism in lung cancer: An overview with focus on EGFR-Mutated non-small cell lung cancer

K Eltayeb, S La Monica, M Tiseo, R Alfieri, C Fumarola - Cells, 2022 - mdpi.com
Lung cancer is the leading cause of cancer deaths worldwide. Most of lung cancer cases are
classified as non-small cell lung cancers (NSCLC). EGFR has become an important …

Serum-integrated omics reveal the host response landscape for severe pediatric community-acquired pneumonia

Y Wang, X Huang, F Li, X Jia, N Jia, J Fu, S Liu… - Critical Care, 2023 - Springer
Objective Community-acquired pneumonia (CAP) is the primary cause of death for children
under five years of age globally. Hence, it is essential to investigate new early biomarkers …

[HTML][HTML] Modulation of host glutamine anabolism enhances the sensitivity of small cell lung cancer to chemotherapy

M Kodama, G Toyokawa, O Sugahara, S Sugiyama… - Cell Reports, 2023 - cell.com
Small cell lung cancer (SCLC) is one of the deadliest human cancers, with a 5-year survival
rate of∼ 7%. Here, we performed a targeted proteomics analysis of human SCLC samples …

Molecular and metabolic alterations of 2,3-dihydroquinazolin-4(1H)-one derivatives in prostate cancer cell lines

LA Dahabiyeh, W Hourani, W Darwish, F Hudaib… - Scientific Reports, 2022 - nature.com
Prostate cancer (PC) is the second most common tumor in males worldwide. The lack of
effective medication and the development of multidrug resistance towards current …

KCNK3 inhibits proliferation and glucose metabolism of lung adenocarcinoma via activation of AMPK-TXNIP pathway

G Lin, L Lin, H Lin, W Chen, L Chen, X Chen… - Cell Death …, 2022 - nature.com
Non-small cell lung cancer (NSCLC) is a primary histological subtype of lung cancer with
increased morbidity and mortality. K+ channels have been revealed to be involved in …

Metabolic reprogramming of thyroid cancer cells and crosstalk in their microenvironment

L Bao, T Xu, X Lu, P Huang, Z Pan, M Ge - Frontiers in Oncology, 2021 - frontiersin.org
Metabolism differs significantly between tumor and normal cells. Metabolic reprogramming
in cancer cells and metabolic interplay in the tumor microenvironment (TME) are important …

Codonopsis pilosula water extract delays D-galactose-induced aging of the brain in mice by activating autophagy and regulating metabolism

X Wang, J Kang, X Li, P Wu, Y Huang, Y Duan… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Codonopsis pilosula (C. pilosula), also called “Dangshen”
in Chinese, is derived from the roots of Codonopsis pilosula (Franch.) Nannf.(C. pilosula) …

Differential glutamine metabolism in the tumor microenvironment–studies in diversity and heterogeneity: A mini-review

MD Claiborne, R Leone - Frontiers in Oncology, 2022 - frontiersin.org
Increased glutamine metabolism is a hallmark of many cancer types. In recent years, our
understanding of the distinct and diverse metabolic pathways through which glutamine can …