Cell death is a fundamental biological phenomenon that is essential for the survival and
development of an organism. Emerging evidence also indicates that cell death contributes to …

Over the past decade, numerous advances have been made in the role and regulation of
inflammasomes during pathogenic and sterile insults. An inflammasome complex comprises …

Inflammasome biology is one of the most exciting and rapidly growing areas in immunology.
Over the past 10 years, inflammasomes have been recognized for their roles in the host …

Inflammatory and apoptotic caspases are central players in inflammation and apoptosis,
respectively. However, recent studies have revealed that these caspases have functions …

Inflammasome signalling is an emerging pillar of innate immunity and has a central role in
the regulation of gastrointestinal health and disease. Activation of the inflammasome …

Disease progression is usually accompanied by changes in the biochemical composition of
cells and tissues and their biophysical properties. For instance, hallmarks of cancer include …

The inflammasome is a macromolecular protein complex that mediates proteolytic cleavage
of pro-IL-1β and-IL-18 and induces cell death in the form of pyroptosis. Certain nucleotide …

Recent research has led to novel findings in inflammasome biology and genetics that
altered the diagnosis and management of patients with autoinflammatory syndromes caused …

Immune cells can sense and respond to biophysical cues—from dynamic forces to spatial
features—during their development, activation, differentiation and expansion. These …

Mechanobiology is a rapidly growing research area focused on how mechanical forces and
properties influence biological systems at the cell, molecular, and tissue level, and how …