Regulatory networks structure and signaling pathways dynamics are uncovered in time-and
resource consuming experimental work. However, it is increasingly supported by modeling …

The paper presents a review of models that can be used to describe dynamics of lung
cancer growth and its response to treatment at both cell population and intracellular …

Natural resistance to Mycobacterium tuberculosis (Mtb) infection in some people with HIV
(PWH) is unexplained. We performed single cell RNA-sequencing of bronchoalveolar …

Cytokines are highly conserved between mammals and insects. The present study
examines the multiple effects of interferon-gamma (IFN-γ) application on the immunological …

IL-33 is an alarmin produced by stromal cells and is known to promote airway inflammation.
IL-33 is a critical mediator of steroid-unresponsiveness in severe asthma. We have …

Information coded in DNA is replicated, modified and transmitted from the origins of protein-
based life. Analogies of these processes to information processing, transmission and …

Cyclic GMP-AMP synthase (cGAS) is primarily recognized as a cytosolic DNA sensor,
activating innate immune responses through the stimulator of interferon genes (STING) …

Transcription of almost all mammalian genes occurs in stochastic bursts, however the
fundamental control mechanisms that allow appropriate single-cell responses remain …