Aberrant Ca2+ release-activated Ca2+ (CRAC) channel activity has been implicated in a
number of human disorders, including immunodeficiency, autoimmunity, occlusive vascular …

In non-excitable cells, Orai proteins represent the main channel for Store-Operated Calcium
Entry (SOCE), and also mediate various store-independent Calcium Entry (SICE) pathways …

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths in
men, and the sixth in women. Non-alcoholic fatty liver disease (NAFLD) is now one of the …

The etiology of autism spectrum disorder (ASD) remains unclear; however, the toxic
environmental exposure to oxidative stress has been suggested to play an important role in …

Abstract Store-Operated Ca 2+ entry (SOCE) is recognized as a key mechanism in muscle
physiology necessary to refill intracellular Ca 2+ stores during sustained muscle activity. For …

Neurodegeneration with brain iron accumulation (NBIA) is a group of devastating and life
threatening rare diseases. Adult and early-onset NBIA syndromes are inherited as X …

Ca2+ mobilization in response to cross-linking of IgE bound to its high affinity receptor,
FcεRI, on mast cells is central to immune allergic responses. Stimulated tyrosine …

In steatotic hepatocytes, intracellular Ca 2+ homeostasis is substantially altered compared to
normal. Decreased Ca 2+ in the endoplasmic reticulum (ER) can lead to ER stress, an …

Effective therapy of hypertension represents a key strategy for reducing the burden of
cardiovascular disease and its associated mortality. The significance of voltage dependent L …

Ca2+ ions play a variety of roles in the human body as well as within a single cell. Cellular
Ca2+ signal transduction processes are governed by Ca2+ sensing and Ca2+ transporting …