[HTML][HTML] Molecular mimicry and autoimmunity
Molecular mimicry is one of the leading mechanisms by which infectious or chemical agents
may induce autoimmunity. It occurs when similarities between foreign and self-peptides …
may induce autoimmunity. It occurs when similarities between foreign and self-peptides …
The role of monocytes and macrophages in autoimmune diseases: a comprehensive review
WT Ma, F Gao, K Gu, DK Chen - Frontiers in immunology, 2019 - frontiersin.org
Monocytes (Mo) and macrophages (Mϕ) are key components of the innate immune system
and are involved in regulation of the initiation, development, and resolution of many …
and are involved in regulation of the initiation, development, and resolution of many …
The heterogeneous pathogenesis of type 1 diabetes mellitus
J Ilonen, J Lempainen, R Veijola - Nature Reviews Endocrinology, 2019 - nature.com
Type 1 diabetes mellitus (T1DM) results from the destruction of pancreatic β-cells that is
mediated by the immune system. Multiple genetic and environmental factors found in …
mediated by the immune system. Multiple genetic and environmental factors found in …
Single-cell RNA-sequencing of peripheral blood mononuclear cells reveals widespread, context-specific gene expression regulation upon pathogenic exposure
The host's gene expression and gene regulatory response to pathogen exposure can be
influenced by a combination of the host's genetic background, the type of and exposure time …
influenced by a combination of the host's genetic background, the type of and exposure time …
Viral infections in type 1 diabetes mellitus—why the β cells?
A Op de Beeck, DL Eizirik - Nature Reviews Endocrinology, 2016 - nature.com
Type 1 diabetes mellitus (T1DM) is caused by progressive autoimmune-mediated loss of
pancreatic β-cell mass via apoptosis. The onset of T1DM depends on environmental factors …
pancreatic β-cell mass via apoptosis. The onset of T1DM depends on environmental factors …
Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin …
Impaired insulin secretion is a hallmark of type 2 diabetes (T2D). Epigenetics may affect
disease susceptibility. To describe the human methylome in pancreatic islets and determine …
disease susceptibility. To describe the human methylome in pancreatic islets and determine …
A type 1 diabetes genetic risk score can aid discrimination between type 1 and type 2 diabetes in young adults
OBJECTIVE With rising obesity, it is becoming increasingly difficult to distinguish between
type 1 diabetes (T1D) and type 2 diabetes (T2D) in young adults. There has been …
type 1 diabetes (T1D) and type 2 diabetes (T2D) in young adults. There has been …
Early prediction of autoimmune (type 1) diabetes
SE Regnell, Å Lernmark - Diabetologia, 2017 - Springer
Underlying type 1 diabetes is a genetic aetiology dominated by the influence of specific HLA
haplotypes involving primarily the class II DR-DQ region. In genetically predisposed children …
haplotypes involving primarily the class II DR-DQ region. In genetically predisposed children …
Effect of maternal diabetes on the embryo, fetus, and children: congenital anomalies, genetic and epigenetic changes and developmental outcomes
A Ornoy, EA Reece, G Pavlinkova… - … Research Part C …, 2015 - Wiley Online Library
Introduction Pregestational and gestational diabetes mellitus (PGDM; GDM) are significant
health concerns because they are associated with an increased rate of malformations and …
health concerns because they are associated with an increased rate of malformations and …
The pathogenesis and natural history of type 1 diabetes
MA Atkinson - Cold Spring Harbor perspectives …, 2012 - perspectivesinmedicine.cshlp.org
The purpose of this article is to provide an overview that summarizes much in the way of our
current state of knowledge regarding the pathogenesis and natural history of type 1 diabetes …
current state of knowledge regarding the pathogenesis and natural history of type 1 diabetes …